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ISSN : 1226-9654

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Vol.32 No.2

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Immediate Extinction Renewal Deficit following Pavlovian Fear Conditioning with Mild, but not Strong Footshock Unconditioned Stimulus

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2020, v.32 no.2, pp.213-221
https://doi.org/10.22172/cogbio.2020.32.2.007


& (2020). Immediate Extinction Renewal Deficit following Pavlovian Fear Conditioning with Mild, but not Strong Footshock Unconditioned Stimulus. The Korean Journal of Cognitive and Biological Psychology, 32(2), 213-221, https://doi.org/10.22172/cogbio.2020.32.2.007

Abstract

Impaired extinction following fear conditioning in the immediate past, dubbed immediate extinction deficit (IED) has been repeatedly demonstrated in animal models. However, whether IED is a universal phenomenon across all different intensities of the US is unknown. In the current experiment, we tested the effect of strong vs. mild footshock US during acquisition on the subsequent extinction, retention and renewal. In Exp.1, rats were subjected to Pavlovian fear conditioning with a tone conditioned stimulus (CS, 5kHz, 80dB, ITI between 45~75sec) and footshock unconditioned stimulus (US, 1.0mA). Then they were divided into four groups: immediate extinction (IE); delayed extinction (DE); immediate no-extinction (IE_NO); delayed no-extinction (DE_NO). IE and DE received 30 CS-only trials 10 min or 24 hr after the conditioning, respectively. IE_NO and DE_NO received the same treatment except for the CS. Twenty-four hours later, they all received retention test which was composed of 10 trials of CS-only trials. On the next day, they received renewal test in a different context and received 10 trials of CS-only trials. Consistent with previous studies, Only DE showed reliable extinction and renewal. IE showed extinction deficit. In Exp.2, the same experimental protocol was employed except for the shock intensity (0.4mA). In contrast to the results from Exp.1, both IE and DE showed a reliable extinction. However, only DE showed renewal effect. Taken together, the current result suggests that extinction process (consolidation of extinction memory) following Pavlovian conditioning with weak shock might involve different neural mechanism from that with strong shock.

keywords
즉각소거 결함, 무조건 자극 강도, 즉각소거 후 재발결함, immediate extinction deficit, unconditioned stimulus intensities, immediate extinction renewal deficit

Reference

1.

Baldi, E., Lorenzini, C. A., & Bucherelli, C. (2004). Footshock intensity and generalization in contextual and auditory-cued fear conditioning in the rat. Neurobiology of Learning and Memory, 81, 162-166.

2.

Bisson, J. I., Jenkins, P. L., Alexander, J., & Bannister, C. (1997). Randomised controlled trial of psychological debriefing for victims of acute burn trauma. The British Journal of Psychiatry, 171, 78-81.

3.

Campfield, K. M., & Hills, A. M. (2001). Effect of timing of critical incident stress debriefing (CISD) on posttraumatic symptoms. Journal of Traumatic Stress, 14, 327-340.

4.

Chang, C. H., Berke, J. D., & Maren, S. (2010). Single-unit activity in the medial prefrontal cortex during immediate and delayed extinction of fear in rats. PLoS One, 5(8), e11971.

5.

Dunsmoor, J. E., Kroes, M. C. W., Moscatelli, C. M., Evans, M. D., Davachi, L., & Phelps, E. A. (2018). Event segmentation protects emotional memories from competing experiences encoded close in time. Nature Human Behaviour, 2, 291-299.

6.

Fitzgerald, P. J., Giustino, T. F., Seemann, J. R., & Maren, S. (2015). Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress. Proceedings of the National Academy of Sciences, 112, E3729-3737.

7.

Gray, M. J., & Litz, B. T. (2005). Behavioral interventions for recent trauma: empirically informed practice guidelines. Behavior Modification, 29, 189-215.

8.

Kim, S. C., Jo, Y. S., Kim, I. H., Kim, H., & Choi, J. S. (2010). Lack of medial prefrontal cortex activation underlies the immediate extinction deficit. Journal of Neuroscience, 30, 832-837.

9.

LeDoux, J. E. (2000). Emotion Circuits in the Brain. Annual Review of Neuroscience, 23, 155-184.

10.

Lin, C. H., Lee, C. C., & Gean, P. W. (2003). Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory. Molecular Pharmacology, 63, 44-52.

11.

Maren, S., & Chang, C. H. (2006). Recent fear is resistant to extinction. Proceedings of the National Academy of Sciences, 103, 18020-18025.

12.

McGaugh, J. L. (2000). Memory-a century of consolidation. Science, 287, 248-251.

13.

Milad, M. R., & Quirk, G. J. (2002). Neurons in medial prefrontal cortex signal memory for fear extinction. Nature, 420, 70-74.

14.

Milad, M. R., Vidal-Gonzalez, I., & Quirk, G. J. (2004). Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner. Behavioral Neuroscience, 118, 389-394.

15.

Monfils, M. H., Cowansage, K. K., Klann, E., & LeDoux, J. E. (2009). Extinction-reconsolidation boundaries: key to persistent attenuation of fear memories. Science, 324, 951-955.

16.

Myers, K. M., Ressler, K. J., & Davis, M. (2006). Different mechanisms of fear extinction dependent on length of time since fear acquisition. Learning & Memory, 13, 216-223.

17.

Nader, K., & Einarsson, E. O. (2010). Memory reconsolidation:An update. Annals of the New York Academy of Sciences, 1191, 27-41.

18.

Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000). The role of ventromedial prefrontal cortex in the recovery of extinguished fear. Journal of Neuroscience, 20, 6225-6231.

19.

Totty, M. S., Payne, M. R., & Maren, S. (2019). Event boundaries do not cause the immediate extinction deficit after Pavlovian fear conditioning in rats. Scientific Reports, 9, 9459.

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