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ISSN : 1226-9654

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The selective activation of pain inhibition system after inescapable shock and the role of cholinergic system

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1992, v.4, pp.150-159
So-Hyun Jo (Korea University)
Won-Ho Cho (Kookmin University)
Jo, S., & Cho, W. (1992). The selective activation of pain inhibition system after inescapable shock and the role of cholinergic system. The Korean Journal of Cognitive and Biological Psychology, 4, 150-159.

Abstract

The present experiment was conducted to examine which component of pain inhibition system is selectively active after inescapable electric shock and whether, inspite of naloxone pretreatment, the decrease of pain sensitivity was due to the change of neurochemical substance following drug. In result of assesing the pain sensitivity on using hot-plate apparatus after severe aversiveness of inescapable shock. Nal and Sal group were higher than baseline in the % analgesic rate in training phase. In the testing phase, both Sal-Sal and Nal-Sal group were maintained hypoalgesia but, both Sal-Nal and Nal-Scop group were significantly reduced in compared with each control group. These results indicated that opioid and nonopioid component of pain inhibition system were selectively activated after inescapable shock, and naloxone-nonreversed hypoalgesia was activated by mediation of chlinergic muscarine receptor, in view of that non-opioid hypoalgesia after naloxone pretreatment was reduced by scopolamine treatment. This results suggested that cholinergic drug is an important neurochemical substance in the activation of non-opioid hypoalgesia.

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The Korean Journal of Cognitive and Biological Psychology

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