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ISSN : 1226-9654

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Central Amygdala Dopamine and Stress-Induced Gastric Ulcer in Rats

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1992, v.4, pp.83-96
Hyoun-Kab Chang (Yeungnam University)
Byung-Soo Yoon (Yeungnam University)
Soon-Kwon Park (Yeungnam University)
Chang, H., Yoon, B., & Park, S. (1992). Central Amygdala Dopamine and Stress-Induced Gastric Ulcer in Rats. The Korean Journal of Cognitive and Biological Psychology, 4, 83-96.

Abstract

To investigate the effects of central amygdala dopamine on immobilization stress-induced gastric ulcer in rats, two experiments were conducted. In experiment 1, 6-OHDA(10㎍) was injected bilaterally into central amygdala to destroy dopaminergic neurons. On 7 days after drug treatment the rats were immobilized individually in supine-restraint devicers at 4℃ for 3hrs. The results of experiment 1 were as follows: lesion of dopaminergic neurons in central amygdala aggravated the gastric ulcer induced by stress. In experimemt 2, apomorphine(10㎍), haloperidol(10㎍) and saline were injected bilaterally into central amygdala. At 30min after drug treatment the rats were restrainted at 4℃ for 3hr. The results were as follows: apormophin had an attenuating effect on the gastric ulcers, but haloperidol had an aggravating effect. These results indicate that dopaminergic neurons and dopamine of central amygdala does play an important role in the stress-induced gastric ulcer.

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The Korean Journal of Cognitive and Biological Psychology

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