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ISSN : 1226-9654

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Non-Opioid Analgesia Induced by Naloxone: Effect of Dorsal-Periaqueductal Gray Lesion

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1993, v.5, pp.76-84
So-Hyun Cho (Korea University)
Mi-Sook Seo (Korea University)
Ki-Suk Kim (Korea University)
Cho, S., Seo, M., & Kim, K. (1993). Non-Opioid Analgesia Induced by Naloxone: Effect of Dorsal-Periaqueductal Gray Lesion. The Korean Journal of Cognitive and Biological Psychology, 5, 76-84.

Abstract

Animals exposed to the naloxone-heat pairings reduced their sensitivity to the pain. Naloxone-induced analgesia may be, in nature, non-opioid in that was found in the rat pretreated with naloxone. The present study was conducted to examine the area which is the responsible for the analesia induced by naloxone-heat pairings. Hot-plate apparatus which was thermoregulated automatically at 53±0.5℃ was used for heat stimulus. The latencies for hind-paw lick was recorded as an index of pain sensitivity. The result of present experiment was as follows. Sham operated rats were maintained analgesia which developed in the training phase but, analgesia developed in the rats which belongs to the experimental group in the training phase was reduced to the baseline level after dorsal periaqueductal lesion. This result suggest that dorsal-periaqueductal gray is responsible for the analgesia induced by naloxone.

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The Korean Journal of Cognitive and Biological Psychology

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