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ISSN : 1226-9654

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Vol.6 No.1

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Ventral Medulla at the level of Inferior Olive is Involved in Descending Pain Inhibition Elicited by Stimulating Anterior Pretectal Nucleus in the Rat

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1994, v.6 no.1, pp.15-28
Bae-Hwan Lee (Department of Psychology, Korea University)
Seung-Kil Hong (Department of Physiology, College of Medicine, Korea University)
Chang-Yil Ahn (Department of Psychology, Korea University)
Jin-Hun Sohn (Department of Psychology, Choongnam Nat'l University)
Ki-Suk Kim (Department of Psychology, Korea University)
Lee, B., Hong, S., Ahn, C., Sohn, J., & Kim, K. (1994). Ventral Medulla at the level of Inferior Olive is Involved in Descending Pain Inhibition Elicited by Stimulating Anterior Pretectal Nucleus in the Rat. The Korean Journal of Cognitive and Biological Psychology, 6(1), 15-28.

Abstract

The present study was conducted to determine whether the ventral medulla (VM) at the level of the inferior olive (IO) is involved in descending pain inhibition system including the anterior pretectal nucleus (APTN). Pain sensitivity was assessed using tail-flick test to radiant heat in the rat anaesthetized with pentobarbital. Electrolytic lesions of the VM or microinjections of lidocaine into the VM inhibited the analgesic effects of stimulating the APTN. Electrical stimulation of the VM or microinjections of glutamate into the VM produced analgesic effects similar to those of stimulating the APTN. These results suggest that the VM including the IO is involved in a descending antinociceptive pathway originating in the APTN.

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The Korean Journal of Cognitive and Biological Psychology

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