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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

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뇌의 항유해 작용 기제에 관한 개관: 편도체-뇌간 회로를 중심으로

Review on Amygdala-Brainstem Neural Circuitry of Antinociception

한국심리학회지: 인지 및 생물 / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2008, v.20 no.2, pp.73-94
https://doi.org/10.22172/cogbio.2008.20.2.003
신맹식 (중앙대학교)

초록

위협적인 환경에 노출되는 유기체는 흔히 유해자극에 대한 통각민감성을 감소시킨다. 본 리뷰의 목적은 지금까지 축적되어온 신경생물학적, 신경심리학적 증거를 통합하여 편도체-뇌간의 항유해 작용 기제에 대한 포괄적인 이해를 도모하기 위함이다. 하행성 항유해 작용에 중심적인 역할을 하는 뇌 부위는 PAG 및 RVM을 포함하는 뇌간 영역이다. 편도체는 신경해부학 및 기능적으로 이들 뇌간 영역에 연결되어 있다. 공포자극에 의해 편도체 자신이 활성화되면 차례로 이들 뇌간 영역도 활성화되어 결국 통각감소로 이어진다. 항유해 작용과 관련하여 편도체-뇌간 회로의 신경과학적 토대는 주로 아편물질과 비아편물질 간의 상호작용이다. 본 리뷰는 특히 이 뇌 회로에서 항유해 작용을 담당하는 신경세포의 활성 수준이 주로 뮤 아편물질에 의해 조절되는 억제성 (GABA) 시냅스와, 글루타민, 뉴로텐신 또는 VIP 등의 흥분성 시냅스 간의 신경통합의 결과에 의해 결정된다고 제안한다. 더 나아가 본 저자는, 설치류의 보다 보편적인 공포반응인 동결반응의 측정으로부터 얻어진 주요한 실험적 관찰에 비추어, 편도체의 항유해 작용 기제에 대한 최근의 연구들로부터 얻어진 발견의 의의를 논한다.

keywords
공포, 항유해 작용, 편도체, 뇌간, 비아편물질, 신경회로, fear, antinociception, amygdala, brainstem, non-opioid, neural circuitry., fear, antinociception, amygdala, brainstem, non-opioid, neural circuitry.

Abstract

Exposure of organisms to a threatening environment often reduces their pain sensitivity to peripheral nociceptive stimulation. The present review was processed based on a considerable amount of existing neurobiological/psychological evidence to provide a comprehensive understanding of the amygdala-brainstem neural mechanisms of the stress-induced antinociception. Brainstem areas including the PAG and the RVM are critical for descending antinociception. The amygdala is neuroanatomically and functionally connected to these brainstem areas. Stimulation of the amygdala cells following presentation of fear-inducing stimuli to organisms activates the descending antinociceptive system of the brainstem, leading to inhibition of pain. Antinociception is now believed to arise from interactions between opioid and non-opioid synapses in this brain circuitry. Notably, the activity of an antinociceptive cell in this brain circuitry is suggested to be determined by a fine balance, or neural integration between excitatory (i.e., glutamatergic, neurotensinergic, or VIPergic) input and mu-opioid regulated inhibitory (i.e., GABAergic) input onto this cell. The author further discussed some implications of recent observations on amygdala antinociceptive mechanisms, via reflecting them onto findings from studies on other fear responses including freezing in the rodent.

keywords
공포, 항유해 작용, 편도체, 뇌간, 비아편물질, 신경회로, fear, antinociception, amygdala, brainstem, non-opioid, neural circuitry., fear, antinociception, amygdala, brainstem, non-opioid, neural circuitry.

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