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ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

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편도체 불활성화가 능동회피학습에서 습득된 조건공포의 표현과 능동회피반응의 수행에 미치는 영향

Effects of Amygdala Inactivation on the Expression of Conditioned Fear and the Performance of Active Avoidance

한국심리학회지: 인지 및 생물 / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2008, v.20 no.4, pp.303-320
https://doi.org/10.22172/cogbio.2008.20.4.006
정지운 (전남대학교 심리학과)
임형문 (전남대학교 심리학과)
김문수 (전남대학교)
  • 다운로드 수
  • 조회수

초록

공포학습에서의 편도체의 역할에 대해서는 공포기억이 편도체 내에 저장된다는 견해와 편도체가 뇌의 다른 부위에 공포기억이 저장되는 과정을 조절한다는 견해가 대립하고 있다. 전자 입장의 연구들은 주로 고전적 공포조건형성 과제를, 후자 입장의 연구들은 주로 회피학습, 즉 도구적 조건형성 과제를 사용하여 서로 상충되는 증거들을 제시해왔다. 동물의 반응과 상관없이 자극들이 제시되는 고전적 조건형성과는 달리 회피학습에서는 특정 자극에 대한 공포뿐 아니라 그 자극을 회피하기 위한 운동반응이 습득되어야 한다. 따라서 회피학습 시에 공포기억은 편도체 내에 저장되지만 회피반응을 위한 운동기억은 편도체 이외의 부위에 저장될 가능성이 있다. 그럴 경우 회피학습 후 기억검사 전에 편도체를 불활성화시키면 조건공포의 표현은 방해받더라도 능동회피반응의 수행은 영향을 받지 않을 것이다. 따라서 본 연구는 편도체에 안내관을 심어놓은 쥐들(Sprague-Dawley, 수컷)에게 불빛을 경고자극으로 사용하여 양방향 능동회피학습을 매일 30회씩 3일 동안 시켰다. 다음날, 편도체에 muscimol (4.4 nmol/0.5 ul) 또는 용매를 주입하고 난 직후, 쥐들을 활동성 검사상자에 넣고 불빛에 대한 조건공포를 검사하였다. 이틀 후, 역시 편도체에 muscimol 또는 용매를 주입한 후 능동회피반응을 재훈련시켰다. 그 결과, muscimol 주입에 의한 편도체 불활성화는 조건공포의 표현은 방해했지만 능동회피반응의 수행은 방해하지 않았다. 동일한 동물에게서 편도체 기능의 차단이 두 종류의 기억의 인출에 서로 다른 효과를 가진다는 이 결과는 위의 두 이론의 상충되는 주장을 설명해 줄 수 있는 가능성을 제시한다.

keywords
Active avoidance, Amygdala inactivation, Conditioned fear, Memory modulation, Memory storage, Task difference, 과제차이, 공포조건형성, 기억조절, 능동회피학습, 조건공포, 편도체, muscimol

Abstract

This study examined the effects of amygdala inactivation on the expression of conditioned fear and the performance of active avoidance. Rats, with chronic cannulae placed bilaterally in the amygdala, were given 30 active avoidance training trials for 3 days and 1 or 2 days later tested for conditioned fear and active avoidance immediately after muscimol or buffer injection into the amygdala. As a result, activity to the CS in the amygdala inactivation group was larger than that of controls while performance of active avoidance was not different. In other words, amygdala inactivation impaired expression of conditioned fear but not active avoidance response. These findings suggest that both memory storage and memory modulation, different view about the role of amygdala, are correct in part and the discrepancy between the two stems from the task difference in part. Thus, amygdala seems to be the locus of CS-US association and, at the same time, modulates memory consolidation in other brain regions. It means that neural mechanisms for the expression of conditioned fear and the performance of active avoidance are not the same.

keywords
Active avoidance, Amygdala inactivation, Conditioned fear, Memory modulation, Memory storage, Task difference, 과제차이, 공포조건형성, 기억조절, 능동회피학습, 조건공포, 편도체, muscimol

참고문헌

1.

김문수, (1997) 회피학습의 정도와 공포기억의 강도 사이의 관계: 과학습이 공포를 감소시키는가, 한국심리학회지: 생물 및 생리

2.

김문수, (2002) 회피학습의 정도와 공포기억의 강도 사이의 관계 III: 학습상황 대 검사상황의 맥락변별의 효과, 한국심리학회지: 생물 및 생리

3.

한정수, (1991) 경악반응 측정법, 한국심리학회지: 생물 및 생리

4.

Allen, T. A., (2008) Imaging the spread of reversible brain inactivations using fluorescent muscimol, Journal of Neuroscience Methods

5.

Annau, Z., (1961) The conditioned emotional response as a function of intensity of the US, Journal of Comparative Physiological Psychology

6.

Brioni, J. D., (1989) Involvement of the amygdala GABAergic system in the modulation of memory storage, Brain Research

7.

Chapman, P. F., (1990) Long-term synaptic potentiation in the amygdala, Synapse

8.

Clugnet, M.-C., (1990) Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body, Journal of Neuroscience

9.

Collins, D. R., (2000) Differential fear conditioning induces reciprocal changes in the sensory responses of lateral amygdala neurons to the CS+ and CS-, Learning and Memory

10.

Davis, M., (1997) Roles of the amygdala and bed nucleus of the stria terminalis in fear and anxiety measured with the acoustic startle reflex. Possible relevance to PTSD, Annals of the New York Academy of Sciences

11.

Gentile, C. G., (1986) The role of amygdaloid central nucleus in the retention of differential Pavlovian conditioning of bradycardia in rabbits, Behavioral Brain Research

12.

Gold, P. E., (1975) Memory interference and facilitation with posttrial amygdala stimulation: effect on memory varies with footshock level, Brain Research

13.

Goosens, K. A., (2004) NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala, European Journal of Neuroscience

14.

Hitchcock, J., (1986) Lesions of the amygdala, but not of the cerebellum or red nucleus, block conditioned fear as measured with the potentiated startle paradigm, Behavioral Neuroscience

15.

Horvath, F.E., (1963) Effects of basolateral amygdalectomy on three types of avoidance behavior in cats, Journal of Comparative and Phyiological Psychology

16.

Kesner, R.P., (1982) Brain stimulation: Effects on memory, Behavioral and Neural Biology

17.

Killcross, S., (1997) Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala, Nature

18.

Kim, M., (1993) Electrolytic lesions of the amygdala block acquisition and expression of fear-potentiated startle even with extensive training but do not prevent reacquisition, Behavioral Neuroscience

19.

Kim, M., (1993) Lack of a temporal gradient of retrograde amnesia in rats with amygdala lesion assessed with the fear-potentiated startle paradigm, Behavioral Neuroscience

20.

LeDoux, J. E., (1995) Emotion: clues from the brain, Annual Review of Psychology

21.

LeDoux, J.E., (1990) The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning, Journal of Neuroscience

22.

LeDoux, J.E., (1990) Topographic organization of neurons in the acoustic thalamus that project to the amygdala, Journal of Neurophysiology

23.

Liang, K. C., (1982) Post-training amygaloid lesions impair retetntion of an inhibitory avoidance response, Behavioral Brain Research

24.

Maren, S. , (2000) Auditory fear conditioning increase CS-elicited spike firing in lateral amygdala neurons even after extensive overtraining, European Journal of Neuroscience

25.

Maren, S., (1996) Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: absence of a temporal gradient, Behavioral Neuroscience

26.

Maren, S., (1996) The amygdala and fear conditioning:has the nut been cracked?, Neuron

27.

McGaugh, J. L., (1990) Significance and rememberance: The role of neuromodulatory systems, Psychological Science

28.

Miserendino, M.J.D., (1990) Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala, Nature

29.

Muller, J., (1997) Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli, Behavioral Neuroscience

30.

Pare, D., (2004) New vistas on amygdala networks in conditioned fear, Journal of Neurophysiology

31.

Parent, M. B., (1992) Increased training in an aversively motivated task attenuates the memory- impairing effects of posttraining N-methyl- D-aspartate-induced amygdala lesions, Behavioral Neuroscience

32.

Parent, M. B., (1994) Memory of rats with amygdala lesions induced 30 days after footshock-motivated escape training reflects degree of original training, Behavioral Neuroscience

33.

Parreo, A., (1985) A new stabilimeter for small laboratory animals, Physiology and Behavior

34.

Paxinos, G., (1986) The rat brain in stereotaxic coordinates, Academic Press

35.

Quirk, G. J., (1997) Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala, Neuron

36.

Rogan, M. T., (1997) Fear conditioning induces associative long-term potentiation in the amygdala, Nature

37.

Thatcher, R.W., (1966) Effect of amygdaloid lesions on retention of an avoidance response in overtrained and non-overtrained rats, Psychonomic Science

38.

Tinsley, M. R., (2004) The role of muscarinic and nicotinic cholinergic neurotransmission in aversive conditioning: comparing pavlovian fear conditioning and inhibitory avoidance, Learning and Memory

39.

Tye, K. M., (2008) Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning, Nature

40.

Wilensky, A. E., (2006) Rethinking the fear circuit: The central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning, Journal of Neuroscience

41.

Wilensky, A. E., (1999) Functional inactivation of the amygdala before but not after auditory fear conditioning prevents memory formation, Journal of Neuroscience

42.

Zimmerman, J. M., (2007) The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining, Learning and Memory

한국심리학회지: 인지 및 생물