- P-ISSN1226-9654
- E-ISSN2733-466X
- KCI
장기 기억 과제에서 연합 항목의 범주 관계가 해마 활동에 미치는 영향
The Effects of Categorical Relationship Between Memory Items on Hippocampal Activation in a Long-term Associative Memory Task
민수정 (연세대학교)
한상훈 (연세대학교)
이도준 (연세대학교)
초록
장기 기억 과제에서 연합쌍을 부호화하거나 인출할 때 항목들의 범주 관계가 해마의 신경 활동에 미치는 영향을 관찰하기 위해 기능성 자기공명영상(fMRI) 연구를 수행하였다. 뇌영상을 촬영하는 동안 학습 단계와 검사 단계로 구성된 실험 절차를 총 여덟 차례 반복 실시하였다. 각 단계마다 12개의 연합쌍이 화면에 출현하였다. 학습 단계의 연합쌍 중 절반은 검사 단계에서 그대로 제시되었고 나머지 절반은 재조합되어 제시되었다. 참가자들은 학습 단계에서 연합쌍을 외웠고 검사 단계에서 연합 재인 과제를 수행하였다. 범주 간 연합 조건의 연합쌍은 얼굴과 건물로 구성되었고 범주 내 연합 조건의 연합쌍은 얼굴과 얼굴, 또는 건물과 건물로 구성되었다. 실험 결과, 얼굴-건물 연합쌍에 대한 재인율은 얼굴-얼굴 연합쌍과 건물-건물 연합쌍에 대한 재인율과 다르지 않았다. 그러나 학습 및 검사 단계에서 범주 간 연합 조건에 대해 더 많이 활성화된 덩이소들이 해마를 비롯한 여러 뇌 영역에서 발견되었다. 학습 단계와 검사 단계에서 발견된 해마 덩이소들의 위치는 대체로 겹치지 않았지만, 학습 단계에서 발견된 우반구 해마의 덩이소들은 검사 단계에서도 비슷한 패턴으로 활성화되었다. 이러한 결과는 기억 항목의 지각적, 개념적 유사성이 해마 신경 활동에 영향을 끼친다는 점을 의미하며, 해마의 연합 기능을 규명하기 위해 범주에 대한 이해가 선행되어야 함을 시사한다.
- keywords
- hippocampus, associative memory, domain, fMRI, 해마, 연합 기억, 범주, 기능성자기공명영상(fMRI)
Abstract
An event-related functional magnetic resonance imaging (fMRI) experiment was conducted to test the effects of categorical relationship between memory items on hippocampal activation during encoding and retrieval of long-term associative memory. The experiment alternated a learning and a test phase eight times in the scanner. Each phase presented 12 associative pairs. During a test phase, a half of the learned pairs were repeated and the other half were rearranged. Participants determined if each pair was intact or rearranged. The between-domain association condition presented face-building pairs and the within-domain association condition presented either face-face or building-building pairs. As results, although behavioral performance of associative recognition was not different between the two conditions, many clusters in the hippocampus and the other brain areas showed greater activation in the between-domain association condition both during learning and test phases, confirming and extending a previous observation (Piekema et al., 2009). In the hippocampus, while such clusters were not spatially overlapped between learning and test phases, the clusters defined in the learning phase produced patterns of activation similar to the test phase. Overall, the current study demonstrates that perceptual and conceptual similarity of memory items affects hippocampal activity and suggests that theoretical and empirical understanding about domain is useful to investigate binding functions in the hippocampus.
- keywords
- hippocampus, associative memory, domain, fMRI, 해마, 연합 기억, 범주, 기능성자기공명영상(fMRI)
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