Aging and Efficiency of Brain Functional Networks: Preliminary Study in Korean Women

인간의 뇌 네트워크는 정보처리 효율성을 도모하기 위해 분리와 통합이라는 두 가지 기본 원리에 따라 조직화된다. 본 연구는 휴지상태 fMRI를 이용하여 분리와 통합의 대표적 네트워크 측정치인 전반적 효율성과 국소적 효율성을 중심으로, 국내 여성들의 노화에 따른 뇌 연결성의 변화를 살펴보았다. 연구 참여자는 젊은 여성 14명, 노인 여성 28명이었다. 노인들은 젊은 성인에 비해 전반적 효율성은 작고, 국소적 효율성은 큰 것으로 나타났다. 또한 노인들의 KDRS-2 점수와 전반적 효율성은 정적 상관 경향성을, 국소적 효율성은 유의한 부적 상관을 보였다. 연령이 증가함에 따라 뇌 네트워크는 전반적인 통합성이 감소하는 한편, 근거리의 국지적 연결성이 증가하는 것으로 시사된다. 또한 네트워크 전반적 통합성이 낮고 국지적 연결성이 높을수록 노인들의 인지기능이 낮은 경향이 있었다.

keywords: 노화, 기능적 연결성, 그래프 이론 분석, 전반적 효율성, 국소적 효율성, brain aging, functional connectivity, graph theoretical analysis, global efficiency, local efficiency

Abstract

The human brain networks are organized with two fundamental principles, i.e. segregation and integration, for efficient information processing. This study investigated age-related changes in the brain networks of Korean women, using resting-state fMRI and focusing on local efficiency and global efficiency that represent segregation and integration respectively. Fourteen young adults and 28 old adults participated. Old adults had lower global efficiency but higher local efficiency in the functional brain networks compared with young adults. In addition, global efficiency of old adults was positively associated with the KDRS-2 scores at trend level, and their local efficiency was negatively correlated with the KDRS-2 scores. These results suggest that global integration of the brain network may reduce but short-range local connection increase with aging. In old adults, lower network integration and higher local connection seems to be linked lower cognitive function.

keywords: 노화, 기능적 연결성, 그래프 이론 분석, 전반적 효율성, 국소적 효율성, brain aging, functional connectivity, graph theoretical analysis, global efficiency, local efficiency

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논문 상세

Vol.28 No.4

노화와 두뇌의 기능적 네트워크 효율성: 국내여성들을 대상으로 한 예비연구

Aging and Efficiency of Brain Functional Networks: Preliminary Study in Korean Women

초록

Abstract

참고문헌

한국심리학회지: 인지 및 생물