- 권한신청
- P-ISSN1226-9654
- E-ISSN2733-466X
- KCI
인터넷게임 과사용자의 휴지기 전두선조 기능 연결성 결함
Impaired resting-state functional connectivity of frontostriatal regions in internet game over-user
강은주 (중독.정신건강센터)
초록
본 연구는 인터넷게임중독 성향을 보이는 개인에서 두뇌 보상 회로의 내재적 기능 연결성 특성을 알아보고자 수행되었다. 특히 보상의 쾌락 신호 처리에 관여하는 복측 선조체(ventral striatum)와 가치 평가를 담당하는 복내측 전전두피질(ventromedial prefrontal cortex)를 중심으로 조사가 이루어졌다. 이를 위해 인터넷게임 과사용 집단(n = 18)과 정상대조 집단(n = 20)을 대상으로 휴식상태 fMRI 영상이 획득되었다. 복측 선조체와 복내측 전전두피질을 seed 영역으로 선정하였으며, 이들 영역의 시계열 신호와의 상관계수를 기능 연결성 정도로 가정하고 전체 두뇌 영역에 대해 집단 간 비교 검증을 하였다. 그 결과, 복내측 전전두피질의 기능 연결성에서의 집단 차이는 주의 통제 및 사회적 가치 평가에 관여하는 것으로 알려진 하 두정영역(inferior parietal region)에서 발견되었는데, 정상대조 집단에 비해 인터넷게임 과사용 집단의 기능 연결성이 감소되어 있었다. 추가로 인터넷게임 과사용의 문제가 있는 개인들에서 복측 선조체와 복외측 전전두피질(ventrolateral prefrontal cortex) 간의 부적 기능 연결성의 증가 경향도 발견되었는데, 이는 보상 체계에 대한 정보처리에 미치는 인지 통제의 억제적 영향을 통한 보완 기제를 시사한다. 이러한 결과는 보상 관련 두뇌 영역과 인지 통제나 주의 조절에 관여하는 전두피질 및 두정피질과의 기능 연결성 결함이 인터넷과 과사용 문제에 취약하게 하는 신경학적 기제일 가능성을 시사한다.
- keywords
- 인터넷게임 과사용, 복내측 전전두엽, 복측 선조체, 보상 회로, 내재적 기능 연결성, internet game over-user, vmPFC, ventral striatum, reward system, intrinsic functional connectivity
Abstract
The aim of this research was to examine the intrinsic functional connectivity of the brain reward system in individuals at risk for Internet Gaming Disorder (IGD). Here we focus on the ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC), the key brain regions for reward hedonic processing and evaluation, respectively. Resting state functional magnetic resonance imaging was acquired from 18 young male participants with Internet-game overuse (IO) and 20 comparable normal subjects (NCs) to compare the intrinsic connectivities of the VS and vmPFC as the two seed regions. The group comparison was made between the functional connectivity maps of these two groups, where resting-state functional connectivity was examined using correlation analysis on the signal fluctuations of each voxel and that of a seed region. The results indicate that the vmPFC functional connectivity of the IO group was reduced relative to the NC group in the inferior parietal region, which is known for attention control and social evaluation. In addition, the IO groups exhibited increased negative functional connectivity between the VS and the ventrolateral prefrontal cortex, suggesting a compensatory mechanism via an inhibitory influence of cognitive executive function on the reward system. These observations suggest that impaired functional connectivity between reward processing regions and cognitive control regions in the frontal and parietal areas is a neurological risk factor for IGD.
- keywords
- 인터넷게임 과사용, 복내측 전전두엽, 복측 선조체, 보상 회로, 내재적 기능 연결성, internet game over-user, vmPFC, ventral striatum, reward system, intrinsic functional connectivity
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