- P-ISSN1226-9654
- E-ISSN2733-466X
- KCI
행동 접근 체계(BAS) 민감성과 휴지기 두뇌의 기능적 네트워크: 그래프-이론 분석
Behavioral approach system (BAS) sensitivity and functional brain networks during rest: graph-theory analysis
김진희 (강원대학교)
강은주 (강원대학교)
초록
휴지기 동안 두뇌의 기능적 네트워크 특성은 정신 병리나 인지 처리의 개인차와 관련이 있다고 알려져 있다. 본 연구는 성격 특성 중 하나로 잘 알려진 행동 접근 체계(behavioral approach system, BAS) 민감성 정도의 개인차이가 휴지기 두뇌 네트워크 특성과 같은 생물학적 특성의 차이에 근거하고 있는지를 조사하기 위해 수행되었다. 이를 위하여 정상 성인(N=30)으로부터 아무런 과제를 수행하지 않는 휴지기 동안 fMRI 영상이 획득되었고, 두뇌를 영역(node)간 서로 연결(edge)된 네트워크로 간주하고, 이를 분석하기 위해 그래프 이론 기반 네트워크 분석 방법을 적용하였다. 그 결과, 보상 처리에 관여한다고 알려진 측핵에서 네트워크를 구성하는 다른 영역들에 미치는 영향력에 대한 지표(betweenness)가 BAS 민감성이 높은 개인일수록 더 높은 경향이 있는 것으로 나타났다. 그리고 우반구 시각 피질에서 군집 계수 감소, 국소적 효율성 감소, 그리고 매개중심성의 증가와 같은 특징들이 관찰되어, 국소적 정보처리 보다 광범위한 범위의 네트워크 정보처리가 높은 경향을 보여주었다. 그 외에도 BAS 민감성이 높은 개인에서 우반구 상전두회의 연결성(degree)과 정보처리 효율성(global efficiency)이 감소된 경향이 발견되었다. 본 연구의 결과들은 측핵, 시각 피질, 전두 피질에서 두뇌 네트워크 특성의 개인차가 BAS가 높은 개인들이 보이는 보상 민감성, 자극 추구 성향, 그리고 충동성과 관련이 있음을 시사한다.
- keywords
- functional brain network, graph-theory analysis, behavioral approach system, resting-state fMRI, 기능적 네트워크, 그래프 이론 접근법, 행동 접근 체계(BAS), 휴지 상태 fMRI
Abstract
The properties of functional brain networks during rest are known to be related to individual differences in cognitive processing or psychopathology. Here, we ask if a personality trait, the behavioral approach system (BAS), is based on individual differences in neurobiological substrates, namely those of the resting-state functional brain network. Resting-state fMRI data were acquired for 30 healthy, normal participants during rest, and brain networks were analyzed using a graph-theoretical approach in which the brain is viewed as a network composed of connections (edges) between brain regions (nodes). The influence of the left nucleus accumbens on other brain regions (quantified by the metric ‘betweenness’), was found to greater tendency in those individuals with higher BAS sensitivity. High BAS sensitivity was also related to a higher tendency for global information processing in the network, rather than local information processing in the right visual cortex, as indicated by increased betweenness and decreased clustering and local efficiency. Finally, Higher BAS-sensitivity individuals also showed tendency of decreased connectivity (‘degree’) and information processing efficiency (‘global efficiency’) in the right superior frontal gyrus. These findings suggest that the differences in brain network properties in the nucleus accumbens, visual cortex, and frontal cortex are related to the greater reward sensitivity, high novelty seeking, and greater impulsivity in high-BAS individuals.
- keywords
- functional brain network, graph-theory analysis, behavioral approach system, resting-state fMRI, 기능적 네트워크, 그래프 이론 접근법, 행동 접근 체계(BAS), 휴지 상태 fMRI
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