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ISSN : 1226-9654
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Corticotropin Releasing Factor-Producing Neurons in the Central Amygdala Induces Experience-Dependent Influences on Behavior
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Abstract
The central nucleus of the amygdala (CeA) contains a group of cells that produce a neuropeptide, corticotropin releasing factor (CRF). The literature suggests that CRF in the CeA has a negative effect on behavior, such as increased anxiety and fear. However recent studies reported a conflicting result showing a rewarding effect of CRF. To understand how CRF lead to different behavioral effects, CRF neurons in the CeA were genetically manipulated to express a light-activated cation channel, channelrhodopsin-2, using CRF-cre mice. When the animals were initially tested to press a lever for light delivery in an operant conditioning (OP) and to visit one of two compartment for light presentation in a real-time place preference task (RTPP), CRF activation did not alter animals’ behavior at all. Stimulation of CRF neurons also failed to change animals’ anxiety levels compared to their control group in an elevated plus maze (EPM). After experiencing a lever press for food rewards for 5 days, however, CRF activation in the same mice induced rewarding effects in both OP and RTPP. Using a different set of mice, it was also examined whether CRF activation after forming fear memory resulted in negative effects on behavior. Indeed, CRF activation did not produce any effects before fear conditioning, but the same manipulation significantly elevated anxiety levels in EPM and induced aversive effects in RTPP after fear conditioning. These results demonstrate that CRF neurons can exert either positive or negative impacts on behavior depending on prior experiences.
- keywords
- central amygdala, corticotropin releasing factor, operant conditioning, fear conditioning, 편도체, 부신피질 방출인자, 강화학습, 공포학습, 불안
Reference
Asok, A., Draper, A., Hoffman, A. F., Schulkin, J., Lupica, C. R., & Rosen, J. B. (2018). Optogenetic silencing of a corticotropin-releasing factor pathway from the central amygdala to the bed nucleus of the stria terminalis disrupts sustained fear. Molecular Psychiatry, 23, 914-922.
Britton, K. T., Lee, G., Vale, W., Rivier, J., & Koob, G. F. (1986). Corticotropin releasing factor (CRF) receptor antagonist blocks activating and 'anxiogenic' actions of CRF in the rat. Brain Research, 369, 303-306.
Dedic, N., Kuhne, C., Jakovcevski, M., Hartmann, J., Genewsky, A. J., Gomes, K. S., Anderzhanova, E., Pohlmann, M. L., Chang, S., Kolarz, A., Vogl, A. M., Dine, J., Metzger, M. W., Schmid, B., Almada, R. C., Ressler, K. J., Wotjak, C. T., Grinevich, V., Chen, A., Schmidt, M. V., Wurst, W., Refojo, D., & Deussing, J. M. (2018). Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nature Neuroscience, 21, 803-807.
Donatti, A. F., & Leite-Panissi, C. R. (2011). Activation of corticotropin-releasing factor receptors from the basolateral or central amygdala increases the tonic immobility response in guinea pigs: an innate fear behavior. Behavioural Brain Research, 225, 23-30.
Dunn, A. J., & Berridge, C. W. (1990). Physiological and Behavioral-Responses to Corticotropin-Releasing Factor Administration - Is Crf a Mediator of Anxiety or Stress Responses. Brain Research Reviews, 15, 71-100.
Dunn, A. J., & File, S. E. (1987). Corticotropin-releasing factor has an anxiogenic action in the social interaction test. Hormones and Behavior, 21, 193-202.
Ehlers, C. L., Henriksen, S. J., Wang, M., Rivier, J., Vale, W., & Bloom, F. E. (1983). Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats. Brain Research, 278, 332-336.
Gray, J. M., Vecchiarelli, H. A., Morena, M., Lee, T. T., Hermanson, D. J., Kim, A. B., McLaughlin, R. J., Hassan, K. I., Kuhne, C., Wotjak, C. T., Deussing, J. M., Patel, S., & Hill, M. N. (2015). Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. Journal of Neuroscience, 35, 3879-3892.
Hartley, N. D., Gaulden, A. D., Baldi, R., Winters, N. D., Salimando, G. J., Rosas-Vidal, L. E., Jameson, A., Winder, D. G., & Patel, S. (2019). Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states. Nature Neuroscience, 22, 2000-2012.
Heymann, G., Jo, Y. S., Reichard, K. L., McFarland, N., Chavkin, C., Palmiter, R. D., Soden, M. E., & Zweifel, L. S. (2020). Synergy of Distinct Dopamine Projection Populations in Behavioral Reinforcement. Neuron, 105, 909-920.
Jo, Y. S., Heymann, G., & Zweifel, L. S. (2018). Dopamine Neurons Reflect the Uncertainty in Fear Generalization. Neuron, 100, 916-925.
Jo, Y. S., Namboodiri, V. M. K., Stuber, G. D., & Zweifel, L. S. (2020). Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit. Nature Communications, 11, 422.
Kim, J., Zhang, X., Muralidhar, S., LeBlanc, S. A., &Tonegawa, S. (2017). Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors. Neuron, 93, 1464-1479.
Koob, G. F. (1999). Corticotropin-releasing factor, norepinephrine, and stress. Biological Psychiatry, 46, 1167-1180.
Koob, G. F., Swerdlow, N., Seeligson, M., Eaves, M., Sutton, R., Rivier, J., & Vale, W. (1984). Effects of alpha-flupenthixol and naloxone on CRF-induced locomotor activation. Neuroendocrinology, 39, 459-464.
Lemos, J. C., Wanat, M. J., Smith, J. S., Reyes, B. A., Hollon, N. G., Van Bockstaele, E. J., Chavkin, C., & Phillips, P. E. (2012). Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. Nature, 490, 402-406.
Pearlman, C. A., Jr., Sharpless, S. K., & Jarvik, M. E. (1961). Retrograde amnesia produced by anesthetic and convulsant agents. Journal of Comparative and Physiological Psychology, 54(2), 109-112.
Pitts, M. W., Todorovic, C., Blank, T., & Takahashi, L. K. (2009). The central nucleus of the amygdala and corticotropin-releasing factor: insights into contextual fear memory. Journal of Neuroscience, 29, 7379-7388.
Sanford, C. A., Soden, M. E., Baird, M. A., Miller, S. M., Schulkin, J., Palmiter, R. D., Clark, M., & Zweifel, L. S. (2017). A Central Amygdala CRF Circuit Facilitates Learning about Weak Threats. Neuron, 93, 164-178.
Sara, S. J., & Devauges, V. (1989). Idazoxan, an Alpha-2Antagonist, Facilitates Memory Retrieval in the Rat. Behavioral and Neural Biology, 51, 401-411.
Sara, S. J., & Deweer, B. (1982). Memory Retrieval Enhanced by Amphetamine after a Long Retention Interval. Behavioral and Neural Biology, 36, 146-160.
Sara, S. J., Deweer, B., & Hars, B. (1980). Reticular Stimulation Facilitates Retrieval of a Forgotten Maze Habit. Neuroscience Letters, 18, 211-217.
Sutton, R. E., Koob, G. F., Le Moal, M., Rivier, J., & Vale, W. (1982). Corticotropin releasing factor produces behavioural activation in rats. Nature, 297, 331-333.
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981). Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science, 213, 1394-1397.
Zweifel, L. S., Fadok, J. P., Argilli, E., Garelick, M. G., Jones, G. L., Dickerson, T. M., Allen, J. M., Mizumori, S. J., Bonci, A., & Palmiter, R. D. (2011). Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety. Nature Neuroscience, 14, 620-626.
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