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ISSN : 1226-9654

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Roles of the Amygdala Norepinephine in Fear-Potentiated Startle Responses

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1992, v.4, pp.97-107
Jung-soo Han (Korea University)
Seon-Hi Shin (Korea University)
Ki-Suk Kim (Korea University)
Han, J., Shin, S., & Kim, K. (1992). Roles of the Amygdala Norepinephine in Fear-Potentiated Startle Responses. The Korean Journal of Cognitive and Biological Psychology, 4, 97-107.

Abstract

In many studies, amygdala is considered to be the neural structure that is involved in fear or anxiety, in human and mammals. This paper, using fear-potentiated startle responses as a measure of fear, was to see whether noradrenergic receptors in the amygdala are involved in the expression of fear Rats were implanted with bilateral cannulae aimed at the amygdala. After the conditioning, DSP-4(30㎍/㎕) was injected to the amygdala, DSP-4 selectively produces the degeneration of the noradrenergic receptors only. In addition, we tried to find out whether or not yohimbine, which is known to increase fear and/or anxiety, can produce the potentiated startle responses even after the degeneration of noradrenergicr receptors in the amygdala. For this, before test, yohimbine(1.25mg/kg) was injected systemically. Results showed that animals injected with DSP-4 did not show the potentiated startle responses, and neither did the aniamls with DSP-4 plus yohimbine before test. It may thus be concluded that the no epinephine in the amygdala is necessary for the expression of fear.

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The Korean Journal of Cognitive and Biological Psychology

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