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ISSN : 1226-9654

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Vol.9 No.1

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Effects of Diazepam and Ethanol on Conditioned Freezing in Rats

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1997, v.9 no.1, pp.45-55
Bong-Kyo Chung (Yeungnam University)
Byung-Soo Yoon (Pusan National University)
Chung, B., & Yoon, B. (1997). Effects of Diazepam and Ethanol on Conditioned Freezing in Rats. The Korean Journal of Cognitive and Biological Psychology, 9(1), 45-55.

Abstract

This study investigated the effects of diazepam and ethanol on the conditioned freezing in Sparague-Dawley male rats, using 2-trial conditioned fear test. On the training day, each rat was placed in the observation chamber and 3 min later received shock eight times(1s, 0.6mA) at a VI-3.75 min. schedule. Behavior was observed two times for 10 min immediately after the eight shocks and in the retention test of the next day, according to a time-sampling procedure. During the first observation period, diazepam 5.0mg/kg, ethanol 0.6g/kg or ethanol 1.2g/kg decreased freezing response immediately following the shocks. Animals injected with diazepam 2.0mg/kg, diazepam 5.0mg/kg or ethanol 1.2g/kg on the training day showed a significant decrease in freezing response in retention test under the same drug or saline. This finding that both diazepam and ethanol attenuated the conditioned freezing response suggested that the anxiolytic effect of both diazepam and ethanol is mediated by a common underlying process.

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The Korean Journal of Cognitive and Biological Psychology

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