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ISSN : 1226-9654

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Vol.10 No.1

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The Lesion effects of infralimbic and prelimbic areas of medial prefrontal cortex on the acquisition and extinction of conditioned fear in rats

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1998, v.10 no.1, pp.45-57
Younghwa Yoon (Korea Neuropsychological Research Institute)
Sunseek Min (Korea University)
Minsu Lee (Korea Neuropsychological Research Institute)
Hyuntaek Kim (Korea Neuropsychological Research Institute)
Yoon, Y., Min, S., Lee, M., & Kim, H. (1998). The Lesion effects of infralimbic and prelimbic areas of medial prefrontal cortex on the acquisition and extinction of conditioned fear in rats. The Korean Journal of Cognitive and Biological Psychology, 10(1), 45-57.

Abstract

This study investigated the role of infralimbic(IL) and prelimbic(PL) areas of medial prefrontal cortex on the acquisition and extinction of conditioned fear response in rats using Pavlovian conditioning paradigm. Conditioned fear behavior(freezing response) was measured during both the acquisition and extinction phases of the task. Conditioned fear was measured both to the conditioned stimulus(CS) and to the contextual stimuli during both phases. IL lesion group, PL lesion group, and sham operated group showed similar conditioned fear to the contextual stimuli during acquisition. IL lesion and PL lesion enhanced conditioned fear to the CS in 2nd conditioning day. IL lesion prolonged conditioned fear to the CS(but not to the context) during extinction. PL lesion prolonged conditioned fear both to the CS and to the context during extinction. These results suggest that IL and PL are involved in emotion, especially fear, and that they are important in inhibition of conditioned fear.

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The Korean Journal of Cognitive and Biological Psychology

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