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ISSN : 1226-9654

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Effects of Contralateral Red Nucleus Lesions on the Conditioned Nictitating Membrane Response and Neuronal Response of Cerebellar Dentato - interpositus Nucleus in Rabbits

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1990, v.2, pp.79-92
June-Seek Choi (Korea University)
Ki-Suk Kim (Korea University)
Choi, J., & Kim, K. (1990). Effects of Contralateral Red Nucleus Lesions on the Conditioned Nictitating Membrane Response and Neuronal Response of Cerebellar Dentato - interpositus Nucleus in Rabbits. The Korean Journal of Cognitive and Biological Psychology, 2, 79-92.

Abstract

Multiple unit activity(MUA) was recorded from the cerebellar dentato-interpositus nucleus during classical conditioning of the nictitating membrane response(NMR) in 12 rabbits, with the use of a tone conditioned stimulus(CS: 1kHz, 85㏈ 300msec), and an airpuff unconditioned stimulus(US:100g/cm<sup>2</sup>, 100msec). Comparisons of MUA with the amplitude-time course of NMR show that they are closely related and it supports previous studies that cerebellum is critically involved in acquisition of conditioned NMR. Following 5 days of the acquisition trainning, contralateral red nucleus(RN) was lesioned electrolytically. Results show that lesions of the RN completely abolished the previously established CR but not UR. No signs of CR recovery was seen after the additional 2 days of relearning period. This result is consistent with previous studies which have demonstrated that RN is an essential locus mediating the classically conditioned NMR. Neuronal responses were decrease after lesion. Even though this decrease is not statistically significant, it suggests that red nucleus does not only relay CR to the accessory abducens nucleus but also has some effect on cerebellar neuronal activity through another unidentified pathway.

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The Korean Journal of Cognitive and Biological Psychology

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