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ISSN : 1226-9654

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Vol.22 No.4

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시스템 응고화 이론에 의한 내측 측두엽 손상 환자들의 기억 인출 또는 실패에 대한 역동적인 해석

Reinterpretation of Characteristics of Explicit Memory Retrieval Shown in Medial Temporal Lobe-lesioned Patients: Review of the Systems Consolidation Theory

한국심리학회지: 인지 및 생물 / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2010, v.22 no.4, pp.549-571
https://doi.org/10.22172/cogbio.2010.22.4.007
신맹식 (중앙대학교)
신맹식. (2010). 시스템 응고화 이론에 의한 내측 측두엽 손상 환자들의 기억 인출 또는 실패에 대한 역동적인 해석. 한국심리학회지: 인지 및 생물, 22(4), 549-571, https://doi.org/10.22172/cogbio.2010.22.4.007

초록

외현적 기억정보는 의미 중심으로 정교하게 처리되면 해마에서 장기기억으로 전환하여 비교적 안정적으로 저장된다. 현대의 기억 연구자들에게 많은 관심의 대상되고 있는 시스템 (재)응고화 이론은 외현적 장기기억의 역동적 특성을 강조한다. 즉, 해마에서 형성된 외현적 장기기억의 흔적은 시간이 경과함에 따라 점진적으로 대뇌피질로 옮겨가 저장되며, 이 기억이 재활성화되는 경우에는 다시 해마로 복귀해 새로운 정보를 통합하고 또다시 대뇌피질로 이동함을 반복한다. 이런 이론의 신경심리학적 기초가 되는 자료들은 H.M.을 포함하여 내측 측두엽이 손상된 환자들로부터 얻어졌음에도, 지금까지의 기억에 관한 신경심리학적 연구들은 이들의 각 사례들 간을 서로 직접적으로 연계하여 역동적인 시스템 응고화 과정에 비견하는 설명이 부족하다. 이에, 현행의 리뷰에서는 해마 의존적인 외현적 기억 특성과 관련하여 선행 연구들에서 각기 별개로 기술되어 온 각 내측 측두엽 손상 환자들의 뇌손상 범위에 따른 다양한 기억 인출 상의 특징들을 계열적으로 묶어 역동적인 시스템 (재)응고화 이론에 대입하여 설명했다. 이로써, 현행의 접근은 이들 뇌손상 환자들의 사례를 재고찰하는 데에 일편의 역동적인 해석의 틀을 제공한다는 데에 주요 의의가 있다.

keywords
systems (re)consolidation, explicit memory, medial temporal lobe, hippocampus, cerebral cortex, H.M., 시스템 (재)응고화, 외현적 기억, 내측 측두엽, 해마, 대뇌피질, H.M.

Abstract

Explicit information for memory is believed to be stored relatively stable after its conversion to a long-term memory(LTM) in the hippocampus, following the organism's elaborative processing of it. Systems (re)consolidation addresses the importance of dynamic properties of explicit LTM, and consequently has attracted modern memory researchers. According to this theory, the engram of the explicit LTM formed in the hippocampus transfers gradually to the cerebral cortex as the memory consolidates. When reactivated, the engram tends to return to the hippocampus, leading to the integration of additional pieces of information, and then is retransmitted up to the cerebral cortex. Although considerable neuropsychological data underlying this theory have been obtained from medial temporal lobe-lesioned patients including H.M., modern memory-related researches based on these cases have little addressed a possible direct serial linkage of extents of their brain damages to ranges of their failure in retrieving explicit memory. Furthermore, the researches have little reflected the patients' various aspects seen during their memory retrieval onto the dynamic flow of the explicit LTM during systems (re)consolidation. Therefore, the present review, regarding the hippocampus-dependent explicit memory, accounted for the patients' various characteristics of the memory retrieval depending upon their ranges of brain damage, via serial combination of their discrete individual cases on the basis of the systems (re)consolidation theory. The present approach provides a useful framework in reinterpreting these cases dynamically.

keywords
systems (re)consolidation, explicit memory, medial temporal lobe, hippocampus, cerebral cortex, H.M., 시스템 (재)응고화, 외현적 기억, 내측 측두엽, 해마, 대뇌피질, H.M.

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