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ISSN : 1226-9654

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Vol.12 No.1

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Test of antipsychotic drugs using visual prepulse inhibition paradigm : The lack of effects of a dopamine D<sub>4</sub> receptor blocker L-745,870

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2000, v.12 no.1, pp.75-87
Munsoo Kim (Dept. of Psychology, Chonnam National University)
Kyungman Kim (Collegy of Pharmacy, Chonnam National University)
Kim, M., & Kim, K. (2000). Test of antipsychotic drugs using visual prepulse inhibition paradigm : The lack of effects of a dopamine D<sub>4</sub> receptor blocker L-745,870. The Korean Journal of Cognitive and Biological Psychology, 12(1), 75-87.

Abstract

The problem with typical antipsychotics have been that they induce motor side effects. Therefore, efforts have been focused on developing drugs without such side effects. The prepulse inhibition (PPI) of startle reflex is one of the paradigms used for screening antipsychotics, since PPI is reduced in schizophrenia patients and this PPI deficits can be induced in rats by injecting dopamine agonists. Until now, most studies with this paradigm have used only auditory prepulse stimuli. To ensure the generality of this paradigm, this study used a visual prepulse stimulus and showed that a dopamine agonist, apomorphine, dose-dependently blocks the PPI in rats (Experiment 1). This PPI deficits induced by apomorphine was blocked by typical antipsychotic, haloperidol (Experiment 2). Finally, the hypothesis that dopamine D<sub>4</sub> receptor is preferentially involved in mediating the antipsychotic effects of drugs was examined by using a selective D<sub>4</sub> receptor blocker, L-745,870. The results showed that L-745,870 did not block the effects of apomorphine (Experiment 3).

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The Korean Journal of Cognitive and Biological Psychology

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