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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

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연합기억과제의 특성과 해마 활성화에 대한 fMRI 연구

Types of Associative Memory Task and Hippocampal Activations: an fMRI Study

한국심리학회지: 인지 및 생물 / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2005, v.17 no.4, pp.477-498
강혜진 (서울대학교)
이동수 (서울대학교)
강은주 (강원대학교)
이정모 (성균관대학교)
나덕렬 (성균관대학교)
나동규 (서울대학교)

초록

본 연구는 해마가 관여하는 연합기억의 유형을 규명하고자 두 종류의 서로 다른 연합기억 과제를 비교하여, 해마가 활성화 되는 연합기억 과제가 어떤 과제인가를 알아보고자 하였다. 연합 기억의 부호화와 재인 동안 활성화 되는 영역을 정상 성인들(N=16)을 대상으로 fMRI를 이용하여 연구하였다. 연합 기억 과제의 유형에 따라, 명명가능한 선형그림 자극을 그 자극이 제시되었던 위치(좌/우)와 함께 기억하여야 하거나(그림-위치 과제), 인위적으로 짝지워진 다른 선형그림과 함께 기억(그림-그림 과제) 기억 할 것이 요구되었다. 응시 기저 조건에 비하여, 해마는 그림-그림 과제 동안 부호화와 인출 중에 활성화 되었으나 그림-위치 과제 동안은 활성화 되지 않았다. 시각피질과 좌측 전전두엽 및 두정엽의 활성화가 두 과제 모두에서 관찰되었으나 공간적 주의, 또는 탐색이 요구되었을 그림-위치 과제동안에만 우측 상소구에서 활성화가 관찰되었다. 본 연구의 결과는 기억해야 할 정보의 유형의 특성에 따라 해마가 연합기억에 선택적으로 관여함을 시사한다.

keywords
연합기억, 해마, 상소구, associative memory, hippocampus, superior colliculus, fMRI

Abstract

In this study, two different associative memory tasks were compared in order to elucidate the types of associative memory in which hippocampus is involved. Brain regions activated during encoding and/or recognition of associative memories were investigated with fMRI in two different associative memory tasks with normal heathy volunteers (N=16). Depending on the types of the task, an namable line-drawing object was to be remembered with its presentation position (left/right) (object-position task) or with arbitrarily paired another object (object-object task). In comparison to fixation rest condition, hippocampus was activated both during encoding and recognition of the object-object associative memory task, but not during the object-position associative memory task. Various cortical regions were activated in both associative tasks, including visual cortex, parietal and prefrontal regions, and cingulate. However, the superior colliculus activation was found in the right hemisphere only during the object-position associative memory task, in which spatial attention or search might be required. These findings suggested that hippocampus is selectively involved in associative memory tasks depending on the types of information to be memorized.

keywords
연합기억, 해마, 상소구, associative memory, hippocampus, superior colliculus, fMRI

참고문헌

1.

강은주, (2002) PET과 fMRI를 이용한 기억의 기능해부학 연구 및 임상적 적용, 한국심리학회지: 인지 및 생물

2.

강은주 ; 김희정 ; 김성일 ; 나동규 ; 이경민 ; 나덕렬 ; 이정모, (2002) 그림의 부호화 과정과 신경기제 : fMRI 연구, 인지과학

3.

김향희, (1997) 한국판 보스톤 이름대기 검사 K-BNT,

4.

Achim,A.M, (2005) Neural correlates of memory for items and for associations:an event-related functional magnetic resonance imaging study,

5.

Butter, (1979) Contrasting effects of lateral striate and superior colliculus lesions on visual discrimination performance in rhesus monkeys Journal of Comparative Physiological Psychology,

6.

(1999) Hippocampal system and declarative (relational) memory: Summarizing the data from functional neuroimaging studies.,

7.

(1997) Dissociating prefrontal and hippocampal function in episodic memory encoding,

8.

(2003) Human hippocampal and parahippocampal activity during visual associative recognition memory for spatial and nonspatial stimulus configurations Journal of Neuroscience,

9.

(2004) From Conditioning to Conscious Recollection Memory System of the Brain, Oxford University Press

10.

(1997) Separate neural bases of two fundamental memory processes in the human medial temporal lobe,

11.

(1995) Impaired use of organizational strategies in free recall following frontal lobe damage,

12.

(1997) Human hippocampus establishes associations in memory,

13.

(1999) Human hippocampus associates information in memory Proceedings of the National Academy of Sciences,

14.

(1976) Relational information and the context effect in recognition memory,

15.

(1978) Item and relational information:A case for context independent retrieval,

16.

(2001) An fMRI study of the functional neuroanatomy of picture encoding in younger and older adults,

17.

(1999) A cognitive activation study of memory for spatial relationships,

18.

(2000) Functional activation of the left amygdala and hippocampus during associative encoding,

19.

(2000) Neural correlates of semantic associative encoding in episodic memory,

20.

(1997) Right medial temporal-lobe contribution to object-location memory Philosophical Transactions of the Royal Society of London,

21.

(1998) Associative encoding of pictures activates the medial temporal lobes,

22.

(1999) Neuronal correlates of encoding and retrieval in episodic memory during a paired-word association learning task,

23.

(1982) A theory for the storage and retrieval of item and associative information,

24.

(1997) Visuo-motor conditional associative learning after frontal and temporal lesions in the human brain,

25.

(2003) Encoding of novel picture pairs activates the perirhinal cortex,

26.

(1985) Inhibition of return,

27.

(2003) Distinct prefrontal cortex activity associated with item memory and source memory for visual shapes,

28.

(1980) A standardized set of 260 pictures Norms for nameagreement Journal of Experimental Psychology,

29.

Sommer, (2005) Dissociable contributions within the medial temporal lobe to encoding of object-location associations,

30.

A, (2003) fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease Journal of Neurology,

31.

Strange, (1999) Segregating the functions of human hippocampus Proceedings of the National Academy of Sciences,

32.

new York, (1988) Co-planar Stereotaxic Atlas of the Human Brain, Thieme Medical Publishers

33.

A, (2001) parahippocampal and occipital- temporal contributions to associative and item recognition memory,

34.

A, (2001) parahippocampal and occipital- temporal contributions to associative and item recognition memory,

한국심리학회지: 인지 및 생물