The present study was to explore the relations among N, E, O (3 factors out of The Big Five Personality Factors), uplifts/hassles, and subjective well-being (SWB). The measurements utilized in the present study were NEO-PI-R (Costa & McCrae, 1992), The Uplifts Scales and The Hassles Scales (Kanner et als., 1981), and MUNSH (Kozma & Stones, 1980). The participants were 365 undergraduate students (155 men and 210 women). The data were analyzed by the SPSS/PC+ statistical package. The employed statistical methods were simple correlations analysis and multiple regression analysis. Results were as follows; a) Neuroticism correlated negatively with the scores of SWB, but Extraversion did positively. There was no significant relations between Openness to Experience and SWB. b) Only in cases of women, the frequency of uplifts and the intensity of hassles were found to be correlated with SWB. c) Personality factors, not life experiences, were important in explaining SWB. In addition, Neuroticism, among personality factors, was the most important one, followed by Extraversion. d) Interaction between uplifts/hassles and personality improved with just a little more variance the explanatory power for the scores of SWB.