The Korean Journal of Health Psychology
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Genetic Influences on Anxiety Sensitivity in Adults Twins and Twin Family Study:Relationships of Depression, Alcohol Dependence, and Nicotine Dependence
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Abstract
Abnormally high anxiety sensitivity, the fear of anxiety-related sensations, has been used to explain the main mechanism of anxiety disorder, such as phobia or panic disorders. The aim of the current study is to examine the extent of genetic contributions to anxiety sensitivity by comparing healthy adult (>30 ys. old) monozygotic (MZ) twins (N = 278 pairs) with that of dizygotic (DZ) twins (N = 80 pairs). Data were obtained from several scales, including the ASI-R(The Revised Anxiety Sensitivity Index), CES-D (Center for Epidemiologic Studies Depression Scale), AUDIT (Alcohol Use Disorders Identification Test), and FTND (Fagerstrom Test of Nicotine Dependence) scales. Heritability of anxiety sensitivity was computed using MERLINE. Using multiple regressions, the relationships of four subscales of anxiety sensitivity and the other psychological maladjustments (depression, alcohol dependence, and nicotine dependence) were examined, separately, for individuals in the MA and DZ groups. There was a significant correlation of anxiety sensitivity scores between twins for the MZ group but not for that of the DZ group. The total heritability estimate of anxiety sensitivity was about 20% the heritability estimate of sub-scales of anxiety sensitivity measure was 21% for cardiovascular concerns, 19% for social concerns, 16% for respiratory sensation concerns, and 13% for psychological concerns. Two of the four subscales anxiety sensitivity(psychological concerns and respiratory sensation concerns) were correlated with depression, but only for the MZ group. These findings for genetic contributions to anxiety sensitivity indicate that anxiety sensitivity is a risk factor of many psychological disorders. Therefore, family-based therapy should be considered in approaching anxiety sensitivity which is related to psychological disorders.
- keywords
- twin, anxiety sensitivity, heritability, depression, alcohol dependence, nicotine dependence, 쌍둥이, 불안민감성, 유전율, 우울, 음주, 흡연
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