The Korean Journal of Health Psychology
- Log In/Sign Up
- KOREAN
- P-ISSN1229-070X
- E-ISSN2713-9581
- KCI
Genetic Influences on Anxiety Sensitivity in Adults Twins and Twin Family Study:Relationships of Depression, Alcohol Dependence, and Nicotine Dependence
Abstract
Abnormally high anxiety sensitivity, the fear of anxiety-related sensations, has been used to explain the main mechanism of anxiety disorder, such as phobia or panic disorders. The aim of the current study is to examine the extent of genetic contributions to anxiety sensitivity by comparing healthy adult (>30 ys. old) monozygotic (MZ) twins (N = 278 pairs) with that of dizygotic (DZ) twins (N = 80 pairs). Data were obtained from several scales, including the ASI-R(The Revised Anxiety Sensitivity Index), CES-D (Center for Epidemiologic Studies Depression Scale), AUDIT (Alcohol Use Disorders Identification Test), and FTND (Fagerstrom Test of Nicotine Dependence) scales. Heritability of anxiety sensitivity was computed using MERLINE. Using multiple regressions, the relationships of four subscales of anxiety sensitivity and the other psychological maladjustments (depression, alcohol dependence, and nicotine dependence) were examined, separately, for individuals in the MA and DZ groups. There was a significant correlation of anxiety sensitivity scores between twins for the MZ group but not for that of the DZ group. The total heritability estimate of anxiety sensitivity was about 20% the heritability estimate of sub-scales of anxiety sensitivity measure was 21% for cardiovascular concerns, 19% for social concerns, 16% for respiratory sensation concerns, and 13% for psychological concerns. Two of the four subscales anxiety sensitivity(psychological concerns and respiratory sensation concerns) were correlated with depression, but only for the MZ group. These findings for genetic contributions to anxiety sensitivity indicate that anxiety sensitivity is a risk factor of many psychological disorders. Therefore, family-based therapy should be considered in approaching anxiety sensitivity which is related to psychological disorders.
- keywords
- twin, anxiety sensitivity, heritability, depression, alcohol dependence, nicotine dependence, 쌍둥이, 불안민감성, 유전율, 우울, 음주, 흡연
Reference
강길태 (2006). 불안민감성과 공황에 대한 스트레스의중재효과 및 공황에 따른 스트레스 대처방식.경상대학교 석사학위논문.
김옥수, 김애정, 김선화, 백성희 (2001). 미혼 흡연여성들의 불안, 우울 및 자아존중감이 흡연양 및니코틴의존도에 미치는 영향. 성인간호학회지.13(4), 509-516.
김지혜, 유범희, 오강섭, 양종철, 김율리, 이소영, 임영진(2004). 한국어 확장판 불안 민감도지수의 타당화 연구. 신경정신의학. 43(1), 54-61.
김형섭 (2000). 불안-우울증의 치료. 대한정신약물학회지. 11(2), 111-116
안희경, 이화진, 정도식, 이선영, 김성원, 강재언 (2002).한국어판 니코틴 의존도 설문도구(FTQ와FTND)의 신뢰도와 타당도. 가정의학회지.23(8), 999-1008
임영진, 이소영, 김지혜 (2005). 불안민감도와 특질불안의 차별성과 공통성: 부적정서, 정적정서, 생리적 과각성간의 관계. 한국심리학회지: 임상,24(2)), 439-449.
유희정 (2001). 불안민감성의 개념과 작용에 대한 개관.한국심리학회: 임상, 20, 195-205.
이병욱, 이충현, 이필구, 최문종, 남궁기 (2000). 한국어판 알코올 사용장애 진단검사(AUDIT)의 개발:신뢰도 및 타당도 검사. 한국중독정신의학.4(2), 83-92.
전겸구, 이민규 (1992). 한국판 CES-D 개발연구 Ⅰ. 한국심리학회지. 11(1), 65-76.
조용래 (2004). 한국판 불안민감성 지표의 요인구조: 위계적 모형에 대한 확인적 요인분석. 한국심리학회지: 임상, 23, 207-220.
조용래, 이경선 (2006). 불안민감성의 사회적 염려차원이 발표상황에 대한 불안반응에 미치는 영향.한국심리학회지 : 임상, 25권 1호, 187-203.
허윤미 (2000). 행동유전학 방법을 통한 인간 행동의 이해. 한국심리학회지: 일반, 19권 2호, 101-122.
허윤미 (2005). 아동의 자아개념에 미치는 유전과 환경의 영향: 쌍둥이 연구. 한국심리학회지: 사회및 성격, 19권 2호, 91-102.
홍숙기 (2003). 성격심리(하). 박영사.
Abecasis, G. R., Cherny, S. S., Cookson, W. O. C., & Cardon. L. R. (2002). MERLIN-Rapid analysis of dense genetic maps using sparse gene flow trees. Nature Genetics, 30, 97-101.
Boyed, J. H., Weissman, M. M., Thompson, W. D., & Myers, J. K. (1982). Screening for depression in a community sample. Archives of General Psychiatry, 39, 1195-1200.
Chantarujikapong, S I., Scherrer, J. F., Xian, H., Eisen, S. A., Lyons, M. J., Goldberg, J., Tsuang, M., & True, W. R. (2001). A twin study of generalized anxiety disorder symptoms, panic disorder symptoms and post-traumatic stress disorder in men. Journal of Psychiatric Research, 103(2-3), 133-145.
Claridge, G. (1995). Origins of Mental Illness. Cambridge MA: Malor Books ISHK.
Cox, B. J., Enns, M. W., & Taylor, S. (2001). The effect of rumination as a mediator of elevated anxiety sensitivity in major depression. Cognitive Therapy and Research, 5, 525-534.
Craig, T., & Van Natta, P. (1978). Current medication use and symptoms of depression in a general population. American Journal of Psychiatry, 135, 1036-1039.
De Haas, R. A., Calamari, J. E., Bair, J. P., & Martin. E. D. (2001). Anxiety sensitivity and drug or alcohol use in individuals with anxiety and substance use disorders. Addictive Behaviors, 26, 787-801.
Eysenck, H. J. (1967). The biological basis of personality. Springfield: Thomas.
Fagerstrom, K. O., & Schneider, N. G. (1989). Measuring nicotine dependence; A review of the Fagerstrom tolerance questionnaire. Journal of Behaviour Medicine, 12, 159-182.
Floderus-Myrhed, B., Pedersen, N., & Rasmunson, I.(1980). Assessment of heritability forpersonality based on a short form of theEysenck Personality Inventory: A studyof 12,898 twin pairs. Behaviour Genetics, 10,153-162
Grant, D. M., Beck, J. G., & Davila, J. (2007). Does anxiety sensitivity predict symptoms of panic, depression, and social anxiety? Behaviour Research and Therapy, 45, 2247-2255.
Hardie, T. L., Moss, H. B., & Lynch, K. G. (2006). Genetic correlations between smoking initiation and smoking behaviors in a twin sample. Addictive Behaviors, 31, 2030-2037.
Heatherton, T. F., Kolzlowski, L. T., & Frecker, R. C.(1991). The Fagerstrom Test for NicotineDependence: arevision of the FagerstromTolerence Questionnaire. British Journal ofAddictiont, 86, 1119-1127.
Jang, K. L., John Livesley, W., Taylor, S. Stein, M. B., & Moon, E. C. (2004). Heritability of individual depressive symptoms. Journal of Affective Disorders, 80, 125-133.
Kendler, K. S., Gatz, M., Gardner, C. O., & Pedersen, N. L. (2006). A Swedish National Twin Study of Lifetime Major Depression. American Journal of Psychiatry, 163, 109-114.
Kendler, K. S., Neale, M. C., McLean, C. J., Heath, A. C., Eaves, L. J., & Kessler, R. C. (1993). Smoking and major depression: a causal analysis. Archives of General Psychiatry, 50, 36-43.
Kendler, K. S., Walters, E. E., Neale, M. C., & Kessler, R. C. (1995). The structure of the genetic and environmental risk factors for six major psychiatric disorders in women: phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Archives of General Psychiatry, 52, 374-383.
Lim, Y. J, Yu, B. H., & Kim, J. H.(2006). Korean anxiety sensitivity index—revised : its factor structure, reliability, and validity In clinical and nonclinical samples. Depression and Anxiety, 23, 1-11.
Maes, H. H., Wooddard, C. E., & Murrelle, L. (1999). Tobacco, Alcohol and Drug Use in Eight-to Sixteen-Year-Old Twins: The Virginia Twin Study of Adolescent Behavioral Development. Journal of Studies on Alcohol, 60, 293-305.
McCabea, R. E., Chudzika, S. M., Antonya, M. M., Younga, L., Swinsona, R. P., & Zolvensky, M. J. (2004). Smoking behaviors across anxiety disorders. Anxiety Disorders, 18, 7– 18.
McNally, R. J., & Eke, M. (1996). Anxiety sensitivity, suffocation fear, and breath-holding duration as predictors of response to carbon dioxide challenge. Journal of Abnormal Psychology, 105, 146–149.
Otto, M. W., Pollack, M. H., Fava, M., Uccello, R., & Rosenbaum, J. F. (1995). Elevated anxiety sensitivity index score in patients with major depression: Correlates and changes with antidepressant treatment. Journal of Anxiety Disorder, 9, 117-121.
Paisey, T. J. H., & Mangan, G. L. (1982), Neo-pavlovian temperament theory and the biological bases of personality, Personality and Individual Differences, 3(2), 189-203.
Pervin, L. A., & John, O. P. (2001). Personality. Theory and research., 8th. Ed. New York: John Wiley & Sons.
Plomin, R., DeFries, J. C., McClearn, G. E., McGuffin, P. (2000). Behavioral Genetics, 4th ed.. New York: Worth Publishers
Radloff, L. S. (1977). The CES-D scale : A selfreport depression scale or research in the general population. Applied Psychological Measurement, 1, 385-401.
Reiss, S., & McNally, R. J. (1985). Expectancy model of fear. In S. Reiss, & R. R. Bootzin, Theoretical issues in behavior therapy. New York: Academic Press.
Reiss, S., Peterson, R. A., Gursky, D. M., & McNally, R. J. (1986). Anxiety sensitivity, anxiety frequency ,and the prediction of fearfulness. Behaviour Research and Therapy, 24, 1-8.
Reiss, S. (1991). Expectancy model of fear, anxiety, and panic. Clinical Psychology Review, 11, 141-153.
Reiss, S. (1997). Trait Anxiety: It's Not What You Think It Is. Journal of Anxiety Disorders, 11(2), 201-214.
Roberts, R. E. (1980). Reliability of the CES-D scale in different ethnic contexts. Psychiatry Research 2, 125-134.
Stein, M. B. (1999). Heritability of Anxiety Sensitivity: A Twin Study. Am J Psychiatry, 156(2), 246-251.
Stewart, S. H., Taylor, S., & Baker, J. M. (1997). Gender Differences in Dimensions of Anxiety Sensitivity. Journal of Anxiety Disorders, 11(2), 179-200.
Stewart, S. H., Karp, J., Pihl, R. O., & Peterson, R. A. (1997). Anxiety sensitivity and selfreported reasons for drug use. Journal of Substance Use, 9, 223-240.
Stewart, S. H., Samoluk, S. B., & McDonald, A. B.(1999). Anxiety sensitivity and substance useand abuse. In : S. Taylor (Ed.), Anxietysensitivity : theory, research, and treatmentof the fear of anxiety, 287-319.
Taylor S., & Cox, B. J. (1998). An Expanded Anxiety Sensitivity Index: Evidence for a Hierarchial Structure Clinical Sample. Journal of Anxiety Disorder, 12, 463-483.
Taylor S., & Koch, W. J. & Woody, S., & McLean, P. (1996). Anxiety sensitivity and depression: how are they related?. Journal of Abnormal Psychology, 105, 474-479.
Taylor, S. (1999). Anxiety sensitivity: theory, research, and treatment of thefear of anxiety. Mahwah, NJ: Erlbaum.
Taylor, S., Jang, K. L., Stewart, S. H., & Stein, M. B. (2008). Etiology of the dimensions of anxiety sensitivity: A behavioral-genetic analysis. Journal of Anxiety Disorder, 22, 899-914
Zvolensky, M. J., Kotov, R., Bonn-Miller, M. O., Schmidt, N. B., & Antipova, A. V. (2008). Anxiety sensitivity as a moderator of association between smoking status and panic-related processes in a representative sample of adults. Journal of Psychiatric Research, 42(1), 69-77.
Ørstavik, R. E,. Kendler, K. S., Czajkowski, N., Tambs, K., & Reichborn-Kjennerud, T. (2007). Genetic and environmental contributions to depressive personality disorder in a population-based sample of Norwegian Twins. Journal of Affective Disorders, 99, 181-189.
Zvolensky, M. J., Schmidt, N. B., & Stewart, S. H.(2003). Panic disorder and smoking. ClinicalPsychology Science and Practice, 10, 29-51.
Zavos, B., Helena, M. S., Gregory, A. M., & Eley, T. C. (2011). Longitudinal genetic analysis of anxiety sensitivity. Developmental Psychology, No Pagination Specified[Epub ahead of print]
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations