This study was conducted with three purposes. First, this study was to investigate the relations among body image esteem, self-esteem and depression of college women. Second, it was to explore that the self-esteem had influence on the body image esteem and depression. Third, it was to examine the effects of cognitive behavior therapy on body image esteem, self-esteem, and depression of college women with negative body image. The data were collected from 244 college women using Body Esteem Test, Body Cathexis Scale, Rogenberge`s Self-Esteem, and Beck Depression Inventory-Korean version. The results of this study were as follows. First, there were significant positive correlations between body image esteem and self-esteem. And there were significant negative correlations between body image esteem and depression of college women. Second, the self-esteem had influence on the body image esteem and the depression. Third, there were significant increase in the body image esteem and the self-esteem in the experimental group. there were significant reductions in the depression between the experimental group and the control group. Finally, the suggestion and limitations of this study were discussed.