Impairment of working memory in patients with schizophrenia

This study investigated the verbal/spatial working memory impairments and the relationship between working memory and neuropsychological functions in patients with schizophrenia. 20 schizophrenic patients and 20 normal controls participated. The verbal working memory and spatial working memory were measured by digit-span test and spatial span test, respectively. The Wisconsin Card Sorting Test(WCST), Trail Making Test(TMT), Controlled Oral Word Association(COWA) and Korean-California Verbal Learning Test(K-CVLT) were administered to evaluate the neuropsychological functions. The schizophrenic patients showed impaired performances on spatial-span test but not on digit-span test, which indicate that schizophrenic patients have spatial working memory deficit but preserved verbal working memory. The schizophrenic patients showed impairments of such neuropsychological functions as attention, problem-solving and verbal memory. In schizophrenic patients, the verbal working memory has significant correlations with response time of TMT and COWA letter, while spatial working memory has a relationship with perseverant responses of WCST. These results indicate that schizophrenic patients have an impairment of spatial working memory, which seems to be related to prefrontal dysfunction

keywords: schizophrenia, verbal working memory, spatial working memory, digit-span test, spatial-span test, 정신분열병, 언어 작업기억, 공간 작업기억, 숫자폭 검사, 공간폭 검사, schizophrenia, verbal working memory, spatial working memory, digit-span test, spatial-span test

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Article Contents

Vol.10 No.1

Impairment of working memory in patients with schizophrenia

Abstract

Reference

The Korean Journal of Health Psychology