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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

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정신분열병 환자의 작업기억 장애

Impairment of working memory in patients with schizophrenia

한국심리학회지: 건강 / The Korean Journal of Health Psychology, (P)1229-070X; (E)2713-9581
2005, v.10 no.1, pp.17-30
김명선 (성신여자대학교)

초록

정신분열병 환자가 언어 작업기억 및 공간 작업기억의 장애를 가지고 있는지, 만약 작업기억의 장애를 가지고 있다면 어떤 신경심리적 기능과 관련되어 있는가를 조사하였으며, 이에 근거하여 정신분열병과 전전두엽 사이의 관련성을 밝히고자 하였다. 언어 작업기억과 공간 작업기억은 각각 숫자폭 검사와 공간폭 검사를 사용하여 측정하였으며, 신경심리적 기능은 위스콘신 카드분류 검사, 선로잇기 검사, 통제단어연상 검사 및 한국판 캘리포니아 언어학습 검사를 사용하여 평가하였다. 정신분열병 환자군은 비교군에 비하여 공간 작업기억 과제의 수행이 유의하게 저하되었으나, 언어 작업기억 과제의 수행에는 두 집단 간의 유의한 차이가 없었다. 정신분열병 환자군은 비교군에 비하여 주의력, 문제해결력 및 언어 기억의 저하를 보였다. 정신분열병 환자군에서 언어 작업기억과 선로잇기의 반응시간 및 통제단어연상검사의 철자단어수와의 상관이 관찰되었고, 공간 작업기억은 위스콘신 카드분류검사의 보속반응 및 보속오반응과 높은 상관을 보였다. 이 결과들은 정신분열병 환자가 공간 작업기억의 장애를 가지고 있으며, 이는 전전두엽의 기능부전과 관련되어 있다는 것을 시사한다.

keywords
schizophrenia, verbal working memory, spatial working memory, digit-span test, spatial-span test, 정신분열병, 언어 작업기억, 공간 작업기억, 숫자폭 검사, 공간폭 검사, schizophrenia, verbal working memory, spatial working memory, digit-span test, spatial-span test

Abstract

This study investigated the verbal/spatial working memory impairments and the relationship between working memory and neuropsychological functions in patients with schizophrenia. 20 schizophrenic patients and 20 normal controls participated. The verbal working memory and spatial working memory were measured by digit-span test and spatial span test, respectively. The Wisconsin Card Sorting Test(WCST), Trail Making Test(TMT), Controlled Oral Word Association(COWA) and Korean-California Verbal Learning Test(K-CVLT) were administered to evaluate the neuropsychological functions. The schizophrenic patients showed impaired performances on spatial-span test but not on digit-span test, which indicate that schizophrenic patients have spatial working memory deficit but preserved verbal working memory. The schizophrenic patients showed impairments of such neuropsychological functions as attention, problem-solving and verbal memory. In schizophrenic patients, the verbal working memory has significant correlations with response time of TMT and COWA letter, while spatial working memory has a relationship with perseverant responses of WCST. These results indicate that schizophrenic patients have an impairment of spatial working memory, which seems to be related to prefrontal dysfunction

keywords
schizophrenia, verbal working memory, spatial working memory, digit-span test, spatial-span test, 정신분열병, 언어 작업기억, 공간 작업기억, 숫자폭 검사, 공간폭 검사, schizophrenia, verbal working memory, spatial working memory, digit-span test, spatial-span test

참고문헌

1.

(1999) Korean-California Verbal Learning Test manual,

2.

(1996) Performance on the Wisconsin card sorting test in schizophrenia perseveration in clinical subtypes,

3.

(1994) Diagnostic and statistical manual of mental disorder,

4.

(1992) Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia assessment with xenon 133 single-photon emission computed tomography and the Tower of London Archives of General Psychiatry,

5.

(1986) Working memory, Oxford University Press

6.

(1998) Recent development in working memory,

7.

(1998) Letter and category fluency in patients with frontal lobe,

8.

(1998) Functional hypofrontality and working memory dysfunction in schizophrenia American Journal of Psychiatry,

9.

(1997) The Halstead Category Test: a fifty year perspective. ,

10.

(2002) Spatial and object working memory impairments in schizophrenia patients Journal of Abnormal Psychology,

11.

(2000) Verbal working memory impairment in schizophrenic patients and their first-degree relatives evidence from digit span task American Journal of Psychiatry,

12.

Working memory functioning in schizophrenia patients and their first-degree relatives cognitive functioning shedding light on etiology, in press

13.

(2001) Saccadic disinhibition in patients with acute and remitted schizophrenia and their first-degree biological relatives American Journal of Psychiatry,

14.

(1996) Standard clinical interview for DSM-IV axis I disorders,

15.

(1997) Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia Archives of General Psychiatry,

16.

(1990) Prefrontal cortical dysfunction in schizophrenia the relevance of working memory, Ravens Press

17.

(1994) Working memory dysfunction in schizophrenia,

18.

(1995) Archtecture of the prefrontal cortex and the central executive,

19.

(2003) Nonverbal working memory deficits in schizophrenia patients:evidence of a supramodal executive processing deficit,

20.

(1996) Verbal fluency deficits in patients with schizophrenia:semantic fluency is differentially impaired as compared with phonological fluency,

21.

(1996) On the nature of Wisconsin card sorting test performance in schizophrenia,

22.

(1981) The Wisconsin card sorting test manual, Psychological Assessment Resources

23.

(2000) Working memory dysfunction and its relevance to schizophrenia Cognition in schizophrenia, Oxford University Press

24.

(1995) Problem solving in schizophrenia a specific deficit in planning ability,

25.

(1992) Schizophrenics show spatial working memory deficits,

26.

(2002) Visual object working memory function and clinical symptoms in schizophrenia,

27.

(2003) Dimensions of working memory dysfunction in schizophrenia,

28.

(1998) Neuroimaging analyses of human working memory,

29.

(1999) Neuropsychological and oculomotor correlates of spatial working memory performance in schizophrenia patients and controls,

30.

(1997) Deficits in multiple systems of working memory in schizophrenia Schizophrenia Research,

31.

(1997) Is Wisconsin card sorting test performance related to 'working memory' capacity? Schizophrenia Research,

32.

(1982) Evidence for the involvement of orbitofrontal cortex in memory function Journal of Comparative and Physiological Psychology,

33.

(1997195-206) Patterns of content and working memory impairments in schizophrenia and nonamnesic alcoholism,

34.

(1985) a primer of neuropsychological evaluation, Churchill Livingstone

35.

(1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia Archives of General Psychiatry,

36.

(1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia Archives of General Psychiatry,

한국심리학회지: 건강