The main purpose of this study is to examine the effect of biogenetic causal explanation and familiarity with mental illness on social distance toward persons with mental disorders. This study was conducted using survey with 2100 adults. Path analysis was used to test a version of a medel in ⅰ) which biogenetic causal explanation influences the prejudice, which in turn influences social distance from persons with mental illness ⅱ) which familiarity influences the prejudice, which in turn influences social distance. The major findings are ⅰ) The more respondents endorse biogenetic causal explanation, the more prejudice they have, more perception of prejudice corresponded closely with more social distance. ⅱ) Respondents who reported to be familiar with mental illness expressed less prejudice and less strong desire for social distance. Our analysis showed that endorsing biogenetic explanation decrease the likelihood of social acceptance of people with mental illness. Our finding fully support the notion that approaches to social change with increase the public's familiarity with mental illness will decrease stigma.
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