This study investigates the moderating effects of coping strategies on the relationship between work, home conflicts and depression, and how these strategies differ depending on gender. In order to this purpose, a questionnaire was administered to dual couples of teachers' group (258 couples). Results showed that the avoidance coping method positively moderated the relationship between depression and the division of household labor in males, In additon to this, the avoidance coping method positively moderated the relationships between depression and division of household labor, child care conflict, job conflict and job ambiguity and job overload in females. From these findings, the differential efficacy of coping strategies by gender was revealed on the relationship between multiple role conflicts and depression experienced by dual employed couples. The controllability of circumstances was implicated as an important factor influencing the efficacy of coping strategies. The results of this study were discussed and the limits of the present study and suggestions for further research were noted.