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The Korean Journal of Health Psychology

  • KOREAN
  • P-ISSN1229-070X
  • E-ISSN2713-9581
  • KCI

The relationship of depression level and depression factors to neuro-cognitive functions in neurological outpatients

The Korean Journal of Health Psychology / The Korean Journal of Health Psychology, (P)1229-070X; (E)2713-9581
2008, v.13 no.2, pp.445-459
https://doi.org/10.17315/kjhp.2008.13.2.009


Abstract

The purpose of this study investigated the differences of depression figure according to diagnosis, and the relation of depression level and depression factors to neuro-cognitive functions. The subjects were 142 patients diagnosed as Alzheimer disease, vascular dementia and mild cognitive impairment. The patients were given brain MRI, neurological examination, the Seoul Neuro-psychological Screening Battery(SNSB), the geriatric depression scale(GDS) and the activity of daily living scale (ADL). The depression rate of Alzheimer patients were the highest compared with other group. However, the vascular dementia showed the highest depression level. In higher depression level, there were significantly lower in attention abilities, psychomotor velocities, visual memory, executive function and ADL. The results of factor analysis for the GDS was classified 4 factors such as depression, worry, dysphoria, and apathy. The depression factor of GDS was related to the attention, immediate visual recall, and executive function. On the other hand, the apathy factor was related to the core symptoms of dementia, such as recall and recognition of memory. Because the depressive symptoms of the dementia patients were often originated from both emotional reaction to their defect and neurological disease itself, the factors of depression might be affected by causes of dementia. So, it is important to ensure that the dementia patients with depression need appropriate treatment through the evaluation of depression factors.

keywords
우울수준, 우울 요인, 무감동 요인, 신경인지기능, 일상생활기능, depression level, depression factor, apathy factor, neuro-cognitive functions, daily activity, depression level, depression factor, apathy factor, neuro-cognitive functions, daily activity

Reference

1.

강연욱, (2003) 서울신경심리검사 Professional manual, 휴브알엔씨

2.

강연욱, (1997) 치매환자들을 대상으로 한 K-MMSE의 타당도 연구, 대한신경과학회지

3.

손석한, (1999) 알쯔하이머형 치매 환자에서 우울증의 유무에 따른 인지기능과 일상생활 수행능력의 차이, 신경정신의학

4.

오은하, (2006) 혈관성 치매 집단에서의 우울증과 인지기능 및 병소의 관계, 한국심리학회지; 임상

5.

정인과, (1998) 한국형 노인우울검사(KGDS) 표준화에 대한 예비연구, 신경정신의학

6.

Adler, G., (2004) Six-month course of mild cognitive impairment and affective symptoms in late-life depression, European Psychiatry

7.

Alexopoulos, G. S., (1997) The vascular depression hypothesis, Archives of General Psychiatry

8.

Amore P., (2007) Subtypes of depression in dementia, Archives of Gerontology and Geriatrics

9.

Butters, N., (1987) Episodic and semantic memory: a comparison of amnestic and demented patients, Journal of Clinical and Experimental Neuropsychology

10.

Chemerinski, E., (2001) The specificity of depressive symptoms in patients with Alzheimer's disease, Journal of Psychiatry

11.

Elderkin-Thompson, V., (2007) Executive dysfunction and memory in older patients with major and minor depression, Archives of Clinical Neuropsychology

12.

(2003) Garre-Olmo, J., L?ez-Pousa, S., Vilalta-Franch, J., Turon-Estrada, A., Hern?dez-Ferr?diz, M., Lozano-Gallego, M., Fajardo-Tibau, C., Puig-Vidal, O., Morante-Mu?z, V., & Cruz-Reina, M., M. (2003), Evolution of depressive symptoms in Alzheimer disease:,

13.

(2005) Holthoff, V. A., Beuthien-Baumann B., Kalbe, E., L?ecke, S., Lenz, O., Z?dorf, G., Spirling, S., Schierz, K., Winiecki, P., Sorbi, S., & Herhotz, K. (2005). Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or,

14.

Knesevich, J. W., (1983) Preliminary report on affective symptoms in early stages of senile dementia of the Alzheimer type, American Journal of Psychiatry

15.

Koenig, H. G., (1993) Profile of depressive symptoms in younger and older medical inpatients with major depression, Journal of American Geriatric Society

16.

Landes, A. M., (2005) Prevalence of apathy, dyphoria, and depression in relation to dementia severity in Alzheimer's disease, Journal of Neuropsychiatry Clinical Neuroscience

17.

Lee,H.B., (2003) Depression in Alzheimer disease: heterogeneity and related issues, Biological Psychiatry

18.

Lyketsos,C.G., (2002) Depression in Alzheimer disease: overview and treatment, Biological Psychiatry

19.

Merriam, A. E., (1988) The psychiatric symptoms of Alzeimer's disease, Journal of American Geriatric Society

20.

(2001) Migneco, O., Benoit M, Koulibaly, P. M., Dygai, I., Bertogliati, C., Desvignes, P., Robert, P. H., Malandain, G., Bussiere, F., & Darcourt, J. (2001). Perfusion brain SPECT and statistical parametirc mapping analysis indicate that apathy is a cingulate sy,

21.

Olin, J. T., (2002) Provisional diagnostic criteria for depression of Alzheimer disease: rational and background, American Journal of Geriatric Psychiatry

22.

Payne, J. L., (1998) Relationship of cognitive and functional impairment to depressive features in Alzhimer's disease and other dementias, Journal of Neuropsychiatry and Clini

23.

Petracca, G. M., (2001) A double-blind placebo-controlled study of fluoxetine in depressed patients with Alzheimer's disease, International Psychogeriatrics

24.

Ready, R. E., (2003) Apathy and executive dysfunction in mild cognitive impairment and Alzheimer disease, American Journal of Geriatric Psychiatry

25.

Reding, M., (1985) Depression in patients referred to a dementia clinic, Archives of Neurology

26.

Starkstein, S. E., (2005) On the overlap between apathy and depression in dementia, Journal of Neurology Neurosurgery and Psychiatry

27.

Starkstein, S.E., (1993) Depression in cerebrovascular disease. In : Depression in Neurological Disease, Johns Hopkins University Press

28.

Strakstein, S. E., (2001) Syndromic validity of apathy in Alzheimer's disease, Journal of Geratric Psychiatry

29.

Strub, L. R., (1992) Differential diagnosis in neuropsychiatry. In : American Psychiatric Association textbook of neuropsychiatry, American Psychiatric Press

30.

Tatch, M. F., (2006) Neuropsychiatric, symptoms in Alzheimer disease and cognitively impaired nondemented elderly from a community-based sample in Brazil, American Journal of Geriatric Psychiatry

31.

Wade,D.T., (1992) Measurement in neurological rehabilitation, Oxford University Press

32.

Walter, H., (2007) Increased left prefrontal activation in patients with unipolar depression; an event-related, parametric, performance- controlled fMRI study, Journal Affective Disorder

33.

Winograd-Gurvich, C., (2006) Negative symptoms: a review of schizophrenia, melancholic depression and Parkinson's disease, Brain Research Bulletin

The Korean Journal of Health Psychology