The purpose of this study investigated the differences of depression figure according to diagnosis, and the relation of depression level and depression factors to neuro-cognitive functions. The subjects were 142 patients diagnosed as Alzheimer disease, vascular dementia and mild cognitive impairment. The patients were given brain MRI, neurological examination, the Seoul Neuro-psychological Screening Battery(SNSB), the geriatric depression scale(GDS) and the activity of daily living scale (ADL). The depression rate of Alzheimer patients were the highest compared with other group. However, the vascular dementia showed the highest depression level. In higher depression level, there were significantly lower in attention abilities, psychomotor velocities, visual memory, executive function and ADL. The results of factor analysis for the GDS was classified 4 factors such as depression, worry, dysphoria, and apathy. The depression factor of GDS was related to the attention, immediate visual recall, and executive function. On the other hand, the apathy factor was related to the core symptoms of dementia, such as recall and recognition of memory. Because the depressive symptoms of the dementia patients were often originated from both emotional reaction to their defect and neurological disease itself, the factors of depression might be affected by causes of dementia. So, it is important to ensure that the dementia patients with depression need appropriate treatment through the evaluation of depression factors.
강연욱, (2003) 서울신경심리검사 Professional manual, 휴브알엔씨
강연욱, (1997) 치매환자들을 대상으로 한 K-MMSE의 타당도 연구, 대한신경과학회지
손석한, (1999) 알쯔하이머형 치매 환자에서 우울증의 유무에 따른 인지기능과 일상생활 수행능력의 차이, 신경정신의학
오은하, (2006) 혈관성 치매 집단에서의 우울증과 인지기능 및 병소의 관계, 한국심리학회지; 임상
정인과, (1998) 한국형 노인우울검사(KGDS) 표준화에 대한 예비연구, 신경정신의학
Adler, G., (2004) Six-month course of mild cognitive impairment and affective symptoms in late-life depression, European Psychiatry
Alexopoulos, G. S., (1997) The vascular depression hypothesis, Archives of General Psychiatry
Amore P., (2007) Subtypes of depression in dementia, Archives of Gerontology and Geriatrics
Butters, N., (1987) Episodic and semantic memory: a comparison of amnestic and demented patients, Journal of Clinical and Experimental Neuropsychology
Chemerinski, E., (2001) The specificity of depressive symptoms in patients with Alzheimer's disease, Journal of Psychiatry
Elderkin-Thompson, V., (2007) Executive dysfunction and memory in older patients with major and minor depression, Archives of Clinical Neuropsychology
(2003) Garre-Olmo, J., L?ez-Pousa, S., Vilalta-Franch, J., Turon-Estrada, A., Hern?dez-Ferr?diz, M., Lozano-Gallego, M., Fajardo-Tibau, C., Puig-Vidal, O., Morante-Mu?z, V., & Cruz-Reina, M., M. (2003), Evolution of depressive symptoms in Alzheimer disease:,
(2005) Holthoff, V. A., Beuthien-Baumann B., Kalbe, E., L?ecke, S., Lenz, O., Z?dorf, G., Spirling, S., Schierz, K., Winiecki, P., Sorbi, S., & Herhotz, K. (2005). Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or,
Knesevich, J. W., (1983) Preliminary report on affective symptoms in early stages of senile dementia of the Alzheimer type, American Journal of Psychiatry
Koenig, H. G., (1993) Profile of depressive symptoms in younger and older medical inpatients with major depression, Journal of American Geriatric Society
Landes, A. M., (2005) Prevalence of apathy, dyphoria, and depression in relation to dementia severity in Alzheimer's disease, Journal of Neuropsychiatry Clinical Neuroscience
Lee,H.B., (2003) Depression in Alzheimer disease: heterogeneity and related issues, Biological Psychiatry
Lyketsos,C.G., (2002) Depression in Alzheimer disease: overview and treatment, Biological Psychiatry
Merriam, A. E., (1988) The psychiatric symptoms of Alzeimer's disease, Journal of American Geriatric Society
(2001) Migneco, O., Benoit M, Koulibaly, P. M., Dygai, I., Bertogliati, C., Desvignes, P., Robert, P. H., Malandain, G., Bussiere, F., & Darcourt, J. (2001). Perfusion brain SPECT and statistical parametirc mapping analysis indicate that apathy is a cingulate sy,
Olin, J. T., (2002) Provisional diagnostic criteria for depression of Alzheimer disease: rational and background, American Journal of Geriatric Psychiatry
Payne, J. L., (1998) Relationship of cognitive and functional impairment to depressive features in Alzhimer's disease and other dementias, Journal of Neuropsychiatry and Clini
Petracca, G. M., (2001) A double-blind placebo-controlled study of fluoxetine in depressed patients with Alzheimer's disease, International Psychogeriatrics
Ready, R. E., (2003) Apathy and executive dysfunction in mild cognitive impairment and Alzheimer disease, American Journal of Geriatric Psychiatry
Reding, M., (1985) Depression in patients referred to a dementia clinic, Archives of Neurology
Starkstein, S. E., (2005) On the overlap between apathy and depression in dementia, Journal of Neurology Neurosurgery and Psychiatry
Starkstein, S.E., (1993) Depression in cerebrovascular disease. In : Depression in Neurological Disease, Johns Hopkins University Press
Strakstein, S. E., (2001) Syndromic validity of apathy in Alzheimer's disease, Journal of Geratric Psychiatry
Strub, L. R., (1992) Differential diagnosis in neuropsychiatry. In : American Psychiatric Association textbook of neuropsychiatry, American Psychiatric Press
Tatch, M. F., (2006) Neuropsychiatric, symptoms in Alzheimer disease and cognitively impaired nondemented elderly from a community-based sample in Brazil, American Journal of Geriatric Psychiatry
Wade,D.T., (1992) Measurement in neurological rehabilitation, Oxford University Press
Walter, H., (2007) Increased left prefrontal activation in patients with unipolar depression; an event-related, parametric, performance- controlled fMRI study, Journal Affective Disorder
Winograd-Gurvich, C., (2006) Negative symptoms: a review of schizophrenia, melancholic depression and Parkinson's disease, Brain Research Bulletin