The aim of this study was to explore factors that could predict female smokers’ self-efficacy for smoking cessation to provide useful information to help them quit smoking. Participants were 337 female smokers. Results of correlation analysis indicated that the higher the craving for smoking or nicotine dependence of female smokers the lower the self-efficacy for smoking cessation, while the more they recognized that weight gain or premenstrual syndrome hindered their smoking cessation, the lower the self-efficacy for smoking cessation. The decision tree model included craving smoking, handling smoking, daily amount of smoking, smoking period, nicotine dependence, and motivation to quit smoking. These findings suggest useful information for future studies. They can also help females stop smoking and construct a program for females’ smoking cessation.