The purpose of this research was to verify the effect of the Mindfulness-Based Cognitive Therapy (MBCT) program for acculturative stress and depression among Chinese overseas, which was conducted by video communication method during the COVID-19 era. Typically, 30 Chinese International Students were selected through random sampling; 15 students were assigned to the experimental group and 15 to the control group. The MBCT program was conducted with the experimental group at the same time by video communication. Eight sessions were carried out to implement the program for 4 weeks (twice a week and 90 minutes per session). The Pre-Post-F/U tests were carried out based on the depression scale (BDI-II) and the acculturation stress scale (ASSIS). Repeated Measurement ANOVA was performed to verify the research question and compare the F/U scores using the Pre scores of the experimental group and the control group as covariates. Furthermore, t verification was performed for the Pre-Post and Post-F/U test of the experimental group and the control group. It was observed that the experimental group members had significantly decreased levels of depression and acculturation stress compared to the control group members, and the effect continued in the F/U-stage. The limitations and implications of this study for future research are also discussed.