본 연구는 한국판 캘리포니아 언어학습검사(K-CVLT)가 치매진단검사로서 효용성을 가지고 있는지를 규명하기 위해 수행되었다. 환자집단은 경희의료원 한방병원 신경정신과 치매클리닉에 내원하는 환자 19명, 통제집단은 서울 동대문구에 거주하는 60세 이상의 정상노인 55명으로 구성되었다. 회상능력을 측정하는 K-CVLT 양적 척도의 대부분에서 두 집단간 유의미한 평균의 차이가 나타났으며, 기억과정을 측정하는 질적 척도의 비교에서는 정상집단이 환자집단에 비해 의미적 군집화를 많이 사용하는 것으로 나타났고, 계열위치 효과에서는 환자집단의 최신효과가 정상집단에 비해 두드러지는 것으로 밝혀졌다. 판별분석결과 장기단서회상과 재인이 두 집단을 가장 잘 변별해 줄 수 있는 변인으로 나타났으며, 민감도 78.9%, 특이도 85.5%, 판별정확률 83.8%로 나타났다. 연구결과를 통해 K-CVLT가 치매환자의 진단에 유용함이 확인되었다.
The aim of this investigation was to examine the clinical utility of the Korean California Verbal Learning Test (K-CVLT) as a staging measure for dementia. The participants were 19 patients with Alzheimer's disease (AD) and 55 age- and education- comparable healthy control (HC) elderly adults who were sampled in Dongdaemun-Gu, Seoul. The results of retrieval related quantitative indices revealed significant mean value differences between HC and AD groups. In the detailed comparison of quantitative indices which measured the process of memory, HC used more semantic clustering than AD. In comparing the serial position effect, AD's recent effects were remarkable than HC. The result of discriminant analysis showed that long term cued recall and recognition scores can be the most efficient indices for discriminating AD to HC with sensitivity and specificity. These results suggest that the K-CVLT has clinical utility in the diagnosis for dementia of Alzheimer type.
(1999) 치매의 신경심리학적 평가,
(2004) Enhanced Cued Recall Task의 유용성 초기 알쯔하이머형 치매 환자와 노인 우울증 환자의 변별,
(1999) K-CVLT: 신경심리학적 기억검사(성인용). , 특수교육
(2002) 초기 알츠하이머형 치매 환자에게 관찰되는 청각사상관련전위 P300요소의 특징,
(1997) Alzheimer형 치매 의심 환자의 신경심리검사 소견,
(2000) 여성 경도 알쯔하이머형 치매군 치매의심군 그리고 비치매 대조군간의 신경인지기능 비교,
(1999) 한국판 기억평가척도(K-MAS)의 타당화 연구. , 고려대학교
(1998) 한국판 치매 평가 검사: Korean Dementia Rating Scale, 학지사
(1980) Diagnostic and statistical manual of mental disorders,
(2001) Stability of the preclinical episodic memory deficit in Alzheimer's disease,
(1994) Preclinical Cognitive Markers of Dementia of the Alzheimer Type,
(1995) Episodic memory changes are associated with the APOE-epolilon 4 allele in nondemented older adults,
(1995) Different components in word-list forgetting of pure amnesics, degenerative demented and healthy subjects.,
(1972) The role of interference and encoding in the short-term memory deficits of Korsakoff patients,
(1984) Age difference in remembering Neuropsychology of memory,
(1988) Integrating clinical assessment with cognitive neuroscience Construct validation of the California Verbal Learning Test Journal of Consulting & Clinical Psychology,
(199119-26) Profiles of demented and amnestic patients on The California Verbal Learning Test Implications for the assessment of memory disorders,
(1998) Cognitive process in preclinical phase of dementia,
(1998) Severity of cognitive impairment in Alzheimer;s disease affects list learning using the California Verbal Learning Test(CVLT).,
(1982) Intrusions as a sign of Alzheimer dementia: Chemical and pathological verification.,
(1990) Object-memory evaluation for prospective detection of dementia in normal functioning eldery Journal of clinical and experimental neuropsychology,
(2000) Memory impairment on free and cued selective reminding predicts dementia,
(1998) The amnestic prodrome of Alzheimer's disease [editorial],
(1997) Cognitive markers preceding Alzheimer's dementia in the healthy old ,
(1995) Neuropsychological detection and characterization of preclinical Alzheimer's disease,
(1988) Verbal memory errors in Alzheimer's and Huntington's dementias,
(1989) Differentiation of Alzheimer's and Parkinson's disease patients on the basis of verbal learning characteristics,
(1996) A nine-word dementia version of the California Verbal Learning Test,
(1995) The 'preclinical phase' of probable Alzheimer's disease: A 13-year prospective study of the Framingham cohort.,
(1991) Tje occurrence of difference intrusive errors in patients with Alzheimer's disease, and major depression
(1984) Clinical diagnosis of Alzheimer's disease Report of the NINCDS-ADRDA Work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease,
Pierre, C. , (2000) Age-related cognitive decline, mild cognitive impairment or preclinical Alzheimer's disease?,
Simon, (1994) Intact primary memory in mild to moderate Alzheimer's disease Indices from the California Verbal Learning Test Journal of clinical and experimental neuropsychology,
Small, B. J., , (1997) Cognitive predictors of incident Alzheimer's disease: a prospective longitudinal study,
(2002) New semantic and serial clustering indices for the California Verbal Learning Test-Second Edition: Background, rationale, and formulae. ,
(1992) Detection and staging of dementia in Alzheimer's disease Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease Archives of Neurology,